ID   RNY_SALTO               Reviewed;         588 AA.
AC   A4X4U3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=Strop_1427;
OS   Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440).
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Salinispora.
OX   NCBI_TaxID=369723;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-916 / DSM 44818 / CNB-440;
RX   PubMed=17563368; DOI=10.1073/pnas.0700962104;
RA   Udwary D.W., Zeigler L., Asolkar R.N., Singan V., Lapidus A., Fenical W.,
RA   Jensen P.R., Moore B.S.;
RT   "Genome sequencing reveals complex secondary metabolome in the marine
RT   actinomycete Salinispora tropica.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:10376-10381(2007).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; CP000667; ABP53893.1; -; Genomic_DNA.
DR   RefSeq; WP_011905325.1; NC_009380.1.
DR   AlphaFoldDB; A4X4U3; -.
DR   STRING; 369723.Strop_1427; -.
DR   EnsemblBacteria; ABP53893; ABP53893; Strop_1427.
DR   KEGG; stp:Strop_1427; -.
DR   PATRIC; fig|369723.5.peg.1454; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_11; -.
DR   OMA; PHAILGM; -.
DR   Proteomes; UP000000235; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..588
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344931"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          278..359
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          404..497
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   588 AA;  64480 MW;  D33418F99333E41D CRC64;
     MNGFDAVLLV AVLLLTVVVV GAVLVGVRAV RGLAGTSRPD DPAFIAEKDR QEQSLAALRS
     AAEEANSTID AAKSAAAAAR TEAAAARAEA KAARAEARRV LDGARAEAEA ILERVHKQAE
     TEAEQLRTAA RRSGEREAAV LAVTTRDQAA EVERRAVRMD DRERLHTEEV ERLAERDRQL
     SAANAALEAR ESALAERDRE LEQAEQRRRR ELERVAGLTA EAARGELVEA IEAQAKREAA
     LRVRDIEAEA RSTGEERARH IVVDAIQRVA SEQTAESVVS VLHLPGDEMK GRIIGREGRN
     IRTFESITGV NLIIDDTPEA VLLSCFDPVR REVGRLTLEK LVLDGRIHPH RIEEVHDLAR
     QEVAQLCQRA AEDALVEVGI TEIHPELVGL LGRLRYRTSY GQNVLKHLVE SAHIAGIMAA
     ELRLDVPTIK RCAFLHDIGK ALTHEVEGSH AIVGADVARR YGESEDVVHA IEAHHNEVPP
     QTVEAVLTQA SDACSGGRPG ARRESLEAYV RRLERIEEIA GGKLGVERVF AMQAGREVRV
     MVRPDDVDDL SASMLARDVA KQIEEELTYP GQIRVTVVRE SRVTEIAR