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RNY_THEFY
ID   RNY_THEFY               Reviewed;         501 AA.
AC   Q47RS4;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=Tfu_0805;
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX;
RX   PubMed=17209016; DOI=10.1128/jb.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G.,
RA   Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B.,
RA   Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; CP000088; AAZ54843.1; -; Genomic_DNA.
DR   RefSeq; WP_011291252.1; NC_007333.1.
DR   AlphaFoldDB; Q47RS4; -.
DR   SMR; Q47RS4; -.
DR   STRING; 269800.Tfu_0805; -.
DR   EnsemblBacteria; AAZ54843; AAZ54843; Tfu_0805.
DR   KEGG; tfu:Tfu_0805; -.
DR   eggNOG; COG1418; Bacteria.
DR   eggNOG; COG1566; Bacteria.
DR   HOGENOM; CLU_028328_1_0_11; -.
DR   OMA; PHAILGM; -.
DR   OrthoDB; 1012190at2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease; RNA-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..501
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344963"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          190..256
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          316..409
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   501 AA;  55188 MW;  AF9F48EED95E5AE2 CRC64;
     MDGVADLVVI ALLGALTLLT AGHVLALRSR SRAVAAQAQQ WADRIRADAE NAARSHQDRL
     LAEAAAYRAE LDRREQRIAA QEQRIERELR RLDAARRQLD ERTAQLDQRA AELARLAEER
     RAVLEQAAAL TAEEAKAALV ADIVDQAKRE AAVLVRAIER DARTNGEARA RRIISLAIQR
     LAGEQTSESV VRAVPLPEEA MKGRIIGREG RNIRAFETVT GVDLIVDDTP GVVLLSCFHP
     LRRETARLTL EKLVADGRIN PHRIEEAYEA SRREVEQQCV RAGEDALLEV GISDMHPELV
     ALLGQLRYRT SYGQNVLAHL VESAHLAGMM AAELGADVPL AKRCALLHDI GKALTHEVEG
     SHAVIGAQLA RRYGECEEVA HAIEAHHNEV EARTVEAVLT QAADAISGGR PGARRASMES
     YVKRLQRMEE IAYAVSDGVE KVFVMQAGRE IRVMVQPEAV DDVQAQVIAR DIAKRVEEEL
     TYPGQVRVTV IRESRAVETA R
 
 
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