ID   RNY_THET8               Reviewed;         574 AA.
AC   Q5SHB3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=TTHA1817;
OS   Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27634 / DSM 579 / HB8;
RA   Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA   Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT   "Complete genome sequence of Thermus thermophilus HB8.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; AP008226; BAD71640.1; -; Genomic_DNA.
DR   RefSeq; WP_011228936.1; NC_006461.1.
DR   RefSeq; YP_145083.1; NC_006461.1.
DR   AlphaFoldDB; Q5SHB3; -.
DR   STRING; 300852.55773199; -.
DR   PRIDE; Q5SHB3; -.
DR   EnsemblBacteria; BAD71640; BAD71640; BAD71640.
DR   GeneID; 3168506; -.
DR   KEGG; ttj:TTHA1817; -.
DR   PATRIC; fig|300852.9.peg.1788; -.
DR   eggNOG; COG0711; Bacteria.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_0; -.
DR   OMA; PHAILGM; -.
DR   PhylomeDB; Q5SHB3; -.
DR   Proteomes; UP000000532; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..574
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344969"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          264..327
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          390..483
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   574 AA;  64577 MW;  4012ADC096A07988 CRC64;
     MSLLDLVLLL LVLGLGGVLL LRRKGEDRSA QEARELLEAA RREAREVLEA ARKEARDILE
     AARQEAKALR QEAEARAKAQ REEVEAELRR RLEAAEAEAK KRLEEAGERL KAEREELRAE
     RERLRSLQEE LKEERERLKA EREELRREGE RLAKRAEALD ARAARLEEAE AELVRKEEAL
     KAEARALEER LKEVERRLYE VAGLTPEEAR RLVLERLDRE LEEEKAQRVR AALERARLEA
     RREAQKILAQ AMQRQASETA AQLAVTVVPI PSDAMKGRII GREGRNIRAF EALTGVDLII
     DDTPDAVLLS SFNPIRREIA RMALEELLKD GRIHPSRIEE VVEKAKQEMK TFIYERGEEA
     ALEAGVVGLK PGLIQLLGRL HFRSSYGQNV LKHSIQVAHL AGIMAAELGL DAALARRAGL
     LHDIGKSVDR EVEGSHVEIG IALARRFGEP KEVVDAIAHH HDPDNAETLY AVLVAAADAL
     SAARPGARRE SLEEYLQRLE ALERIALSFP GVETAFAVQA GREVRVIVKP EKISDAKATL
     LAREIASRIE KEMNYPGQVQ VTVVRETRAV EYAR