RNZ1_BOVIN
ID RNZ1_BOVIN Reviewed; 363 AA.
AC Q29RY4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Zinc phosphodiesterase ELAC protein 1;
DE EC=3.1.26.11;
DE AltName: Full=ElaC homolog protein 1;
DE AltName: Full=Ribonuclease Z 1;
DE Short=RNase Z 1;
DE AltName: Full=tRNA 3 endonuclease 1;
DE AltName: Full=tRNase Z 1;
GN Name=ELAC1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Zinc phosphodiesterase, which displays some tRNA 3'-
CC processing endonuclease activity. Probably involved in tRNA maturation,
CC by removing a 3'-trailer from precursor tRNA (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of RNA, removing extra 3' nucleotides
CC from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy
CC group is left at the tRNA terminus and a 5'-phosphoryl group is left
CC at the trailer molecule.; EC=3.1.26.11;
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 2 Zn(2+) ions. {ECO:0000250};
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC {ECO:0000250}. Note=Mainly cytosolic. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RNase Z family. {ECO:0000305}.
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DR EMBL; BC113356; AAI13357.1; -; mRNA.
DR RefSeq; NP_001039792.1; NM_001046327.1.
DR RefSeq; XP_005224260.1; XM_005224203.3.
DR RefSeq; XP_005224261.1; XM_005224204.3.
DR AlphaFoldDB; Q29RY4; -.
DR SMR; Q29RY4; -.
DR STRING; 9913.ENSBTAP00000007468; -.
DR PaxDb; Q29RY4; -.
DR Ensembl; ENSBTAT00000007468; ENSBTAP00000007468; ENSBTAG00000005683.
DR GeneID; 532568; -.
DR KEGG; bta:532568; -.
DR CTD; 55520; -.
DR VEuPathDB; HostDB:ENSBTAG00000005683; -.
DR VGNC; VGNC:97267; ELAC1.
DR eggNOG; KOG2121; Eukaryota.
DR GeneTree; ENSGT00730000111224; -.
DR HOGENOM; CLU_031317_2_2_1; -.
DR InParanoid; Q29RY4; -.
DR OMA; GTQRQMM; -.
DR OrthoDB; 1387038at2759; -.
DR TreeFam; TF324462; -.
DR Proteomes; UP000009136; Chromosome 24.
DR Bgee; ENSBTAG00000005683; Expressed in anterior segment of eyeball and 106 other tissues.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0042781; F:3'-tRNA processing endoribonuclease activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042779; P:tRNA 3'-trailer cleavage; IBA:GO_Central.
DR CDD; cd07717; RNaseZ_ZiPD-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; -; 1.
DR HAMAP; MF_01818; RNase_Z_BN; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR013471; RNase_Z/BN.
DR Pfam; PF00753; Lactamase_B; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR SUPFAM; SSF56281; SSF56281; 1.
DR TIGRFAMs; TIGR02651; RNase_Z; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Endonuclease; Hydrolase; Metal-binding; Nuclease; Nucleus;
KW Reference proteome; tRNA processing; Zinc.
FT CHAIN 1..363
FT /note="Zinc phosphodiesterase ELAC protein 1"
FT /id="PRO_0000240601"
FT ACT_SITE 66
FT /note="Proton acceptor"
FT /evidence="ECO:0000255"
FT BINDING 62
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 64
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 66
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 67
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 182
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 253
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 253
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 313
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 363 AA; 39979 MW; 2A6886919D497471 CRC64;
MSMDVTFLGT GAAYPSPTRG ASALVLRCEG ECWLFDCGEG TQTQLMKSQL KAGRITKIFI
THLHGDHFFG LPGLLCTISL QSGSMVTKQP IEIYGPVGLR DFIWRTMELS HTELVFPYVV
HELVPTADQC PTEELQESVQ VDKTDNPPKE GEGRTILLDS EENSYLLVDD EQFVVKAFRL
FHRIPSFGFS VVEKKRPGKL NAQKLKDLGV PPGPAYGKLK NGISVVLENG VTISPQDVLK
KPIVGRKICI LGDCSGVVDD AGVKLCFEAD LLIHEATLDD TQMDKAKEHG HSTPQMAATF
AKLCQAKRLV LTHFSQRYKP VALAREGEAD GIVELKKQAE SVLDLQEVTL AEDFMVISIP
IKK
