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RNZ1_HUMAN
ID   RNZ1_HUMAN              Reviewed;         363 AA.
AC   Q9H777; Q9NS99;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Zinc phosphodiesterase ELAC protein 1;
DE            EC=3.1.26.11;
DE   AltName: Full=Deleted in Ma29;
DE   AltName: Full=ElaC homolog protein 1;
DE   AltName: Full=Ribonuclease Z 1;
DE            Short=RNase Z 1;
DE   AltName: Full=tRNA 3 endonuclease 1;
DE   AltName: Full=tRNase Z 1;
GN   Name=ELAC1; Synonyms=D29;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT VAL-355.
RX   PubMed=11401430; DOI=10.1006/geno.2000.6454;
RA   Yanaihara N., Kohno T., Takakura S., Takei K., Otsuka A., Sunaga N.,
RA   Takahashi M., Yamazaki M., Tashiro H., Fukuzumi Y., Fujimori Y.,
RA   Hagiwara K., Tanaka T., Yokota J.;
RT   "Physical and transcriptional map of a 311-kb segment of chromosome 18q21,
RT   a candidate lung tumor suppressor locus.";
RL   Genomics 72:169-179(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11175785; DOI=10.1038/84808;
RA   Tavtigian S.V., Simard J., Teng D.H.F., Abtin V., Baumgard M., Beck A.,
RA   Camp N.J., Carillo A.R., Chen Y., Dayananth P., Desrochers M., Dumont M.,
RA   Farnham J.M., Frank D., Frye C., Ghaffari S., Gupte J.S., Hu R., Iliev D.,
RA   Janecki T., Kort E.N., Laity K.E., Leavitt A., Leblanc G.,
RA   McArthur-Morrison J., Pederson A., Penn B., Peterson K.T., Reid J.E.,
RA   Richards S., Schroeder M., Smith R., Snyder S.C., Swedlund B., Swensen J.,
RA   Thomas A., Tranchant M., Woodland A.-M., Labrie F., Skolnick M.H.,
RA   Neuhausen S., Rommens J., Cannon-Albright L.A.;
RT   "A candidate prostate cancer susceptibility gene at chromosome 17p.";
RL   Nat. Genet. 27:172-180(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Smooth muscle;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   ENZYME ACTIVITY.
RX   PubMed=12711671; DOI=10.1093/nar/gkg337;
RA   Takaku H., Minagawa A., Takagi M., Nashimoto M.;
RT   "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing
RT   endoribonuclease.";
RL   Nucleic Acids Res. 31:2272-2278(2003).
RN   [6]
RP   SUBCELLULAR LOCATION.
RX   PubMed=21593607; DOI=10.4161/rna.8.4.15393;
RA   Brzezniak L.K., Bijata M., Szczesny R.J., Stepien P.P.;
RT   "Involvement of human ELAC2 gene product in 3' end processing of
RT   mitochondrial tRNAs.";
RL   RNA Biol. 8:616-626(2011).
CC   -!- FUNCTION: Zinc phosphodiesterase, which displays some tRNA 3'-
CC       processing endonuclease activity. Probably involved in tRNA maturation,
CC       by removing a 3'-trailer from precursor tRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing extra 3' nucleotides
CC         from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy
CC         group is left at the tRNA terminus and a 5'-phosphoryl group is left
CC         at the trailer molecule.; EC=3.1.26.11;
CC         Evidence={ECO:0000269|PubMed:12711671};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) ions. {ECO:0000250};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21593607}.
CC       Nucleus {ECO:0000269|PubMed:21593607}. Note=Mainly cytosolic.
CC   -!- TISSUE SPECIFICITY: Widely expressed. Expressed in heart, brain,
CC       placenta, lung, liver, skeletal muscle, kidney and pancreas.
CC       {ECO:0000269|PubMed:11401430}.
CC   -!- SIMILARITY: Belongs to the RNase Z family. {ECO:0000305}.
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DR   EMBL; AB029151; BAA96799.1; -; mRNA.
DR   EMBL; AF308695; AAG24917.1; -; mRNA.
DR   EMBL; AK024822; BAB15021.1; -; mRNA.
DR   EMBL; BC014624; AAH14624.1; -; mRNA.
DR   CCDS; CCDS11949.1; -.
DR   RefSeq; NP_061166.1; NM_018696.2.
DR   PDB; 3ZWF; X-ray; 1.70 A; A/B=3-363.
DR   PDBsum; 3ZWF; -.
DR   AlphaFoldDB; Q9H777; -.
DR   SMR; Q9H777; -.
DR   BioGRID; 120694; 3.
DR   STRING; 9606.ENSP00000269466; -.
DR   iPTMnet; Q9H777; -.
DR   PhosphoSitePlus; Q9H777; -.
DR   BioMuta; ELAC1; -.
DR   DMDM; 41017799; -.
DR   EPD; Q9H777; -.
DR   jPOST; Q9H777; -.
DR   MassIVE; Q9H777; -.
DR   MaxQB; Q9H777; -.
DR   PaxDb; Q9H777; -.
DR   PeptideAtlas; Q9H777; -.
DR   PRIDE; Q9H777; -.
DR   ProteomicsDB; 81086; -.
DR   Antibodypedia; 22721; 243 antibodies from 21 providers.
DR   DNASU; 55520; -.
DR   Ensembl; ENST00000269466.8; ENSP00000269466.3; ENSG00000141642.9.
DR   GeneID; 55520; -.
DR   KEGG; hsa:55520; -.
DR   MANE-Select; ENST00000269466.8; ENSP00000269466.3; NM_018696.3; NP_061166.1.
DR   UCSC; uc002lez.4; human.
DR   CTD; 55520; -.
DR   DisGeNET; 55520; -.
DR   GeneCards; ELAC1; -.
DR   HGNC; HGNC:14197; ELAC1.
DR   HPA; ENSG00000141642; Low tissue specificity.
DR   MIM; 608079; gene.
DR   neXtProt; NX_Q9H777; -.
DR   OpenTargets; ENSG00000141642; -.
DR   PharmGKB; PA27738; -.
DR   VEuPathDB; HostDB:ENSG00000141642; -.
DR   eggNOG; KOG2121; Eukaryota.
DR   GeneTree; ENSGT00730000111224; -.
DR   HOGENOM; CLU_031317_2_2_1; -.
DR   InParanoid; Q9H777; -.
DR   OMA; GTQRQMM; -.
DR   OrthoDB; 1387038at2759; -.
DR   PhylomeDB; Q9H777; -.
DR   TreeFam; TF324462; -.
DR   BRENDA; 3.1.26.11; 2681.
DR   PathwayCommons; Q9H777; -.
DR   BioGRID-ORCS; 55520; 6 hits in 1080 CRISPR screens.
DR   ChiTaRS; ELAC1; human.
DR   GeneWiki; ELAC1; -.
DR   GenomeRNAi; 55520; -.
DR   Pharos; Q9H777; Tbio.
DR   PRO; PR:Q9H777; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; Q9H777; protein.
DR   Bgee; ENSG00000141642; Expressed in islet of Langerhans and 128 other tissues.
DR   ExpressionAtlas; Q9H777; baseline and differential.
DR   Genevisible; Q9H777; HS.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0042781; F:3'-tRNA processing endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042779; P:tRNA 3'-trailer cleavage; IBA:GO_Central.
DR   CDD; cd07717; RNaseZ_ZiPD-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   HAMAP; MF_01818; RNase_Z_BN; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR013471; RNase_Z/BN.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   Pfam; PF12706; Lactamase_B_2; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
DR   TIGRFAMs; TIGR02651; RNase_Z; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Endonuclease; Hydrolase; Metal-binding; Nuclease;
KW   Nucleus; Reference proteome; tRNA processing; Zinc.
FT   CHAIN           1..363
FT                   /note="Zinc phosphodiesterase ELAC protein 1"
FT                   /id="PRO_0000155825"
FT   ACT_SITE        66
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         62
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         64
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         66
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         67
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         182
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         253
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         253
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         313
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   VARIANT         355
FT                   /note="M -> V (in dbSNP:rs34524743)"
FT                   /evidence="ECO:0000269|PubMed:11401430"
FT                   /id="VAR_017424"
FT   CONFLICT        314
FT                   /note="F -> S (in Ref. 3; BAB15021)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        358
FT                   /note="S -> G (in Ref. 3; BAB15021)"
FT                   /evidence="ECO:0000305"
FT   STRAND          4..9
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          11..14
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          17..19
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          21..28
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          31..35
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           41..47
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          48..50
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           52..54
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          55..59
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           65..67
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   TURN            68..70
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           71..81
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          91..96
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           99..109
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          118..123
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           127..129
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   TURN            160..163
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          164..169
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          171..184
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          186..193
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          247..251
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          255..257
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           261..265
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   TURN            266..268
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          270..275
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           280..282
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           283..288
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   HELIX           294..303
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          307..312
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          347..350
FT                   /evidence="ECO:0007829|PDB:3ZWF"
FT   STRAND          356..358
FT                   /evidence="ECO:0007829|PDB:3ZWF"
SQ   SEQUENCE   363 AA;  40019 MW;  125A8416502D4C79 CRC64;
     MSMDVTFLGT GAAYPSPTRG ASAVVLRCEG ECWLFDCGEG TQTQLMKSQL KAGRITKIFI
     THLHGDHFFG LPGLLCTISL QSGSMVSKQP IEIYGPVGLR DFIWRTMELS HTELVFHYVV
     HELVPTADQC PAEELKEFAH VNRADSPPKE EQGRTILLDS EENSYLLFDD EQFVVKAFRL
     FHRIPSFGFS VVEKKRPGKL NAQKLKDLGV PPGPAYGKLK NGISVVLENG VTISPQDVLK
     KPIVGRKICI LGDCSGVVGD GGVKLCFEAD LLIHEATLDD AQMDKAKEHG HSTPQMAATF
     AKLCRAKRLV LTHFSQRYKP VALAREGETD GIAELKKQAE SVLDLQEVTL AEDFMVISIP
     IKK
 
 
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