ID   RN_WEICA                Reviewed;         109 AA.
AC   P37203;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Ribonuclease;
DE            EC=3.1.27.-;
DE   AltName: Full=RNase Bco;
OS   Weizmannia coagulans (Bacillus coagulans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Weizmannia.
OX   NCBI_TaxID=1398;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=8220218;
RA   Shlyapnikov S.V., Dementiev A.A.;
RT   "Amino acid sequence and catalytic properties of the Bacillus coagulans
RT   extracellular ribonuclease.";
RL   Dokl. Akad. Nauk 332:382-384(1993).
CC   -!- FUNCTION: Hydrolyzes phosphodiester bonds in RNA, poly- and
CC       oligoribonucleotides resulting in 3'-nucleoside monophosphates via
CC       2',3'-cyclophosphate intermediates.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the ribonuclease N1/T1 family. {ECO:0000305}.
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DR   AlphaFoldDB; P37203; -.
DR   SMR; P37203; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   CDD; cd00933; barnase; 1.
DR   InterPro; IPR001887; Barnase.
DR   InterPro; IPR000026; Gua-sp_ribonuclease_N1/T1/U2.
DR   InterPro; IPR016191; Ribonuclease/ribotoxin.
DR   Pfam; PF00545; Ribonuclease; 1.
DR   PIRSF; PIRSF001013; Barnase; 1.
DR   PRINTS; PR00117; BARNASE.
DR   SUPFAM; SSF53933; SSF53933; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endonuclease; Hydrolase; Nuclease; Secreted.
FT   CHAIN           1..109
FT                   /note="Ribonuclease"
FT                   /id="PRO_0000137366"
FT   ACT_SITE        72
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        101
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   109 AA;  12182 MW;  6EC8CA58F0D29B96 CRC64;
     AVINTFDGVA DYLIRYKRLP DNYITKSQAS ALGWVASKGN LAEVAPGKSI GGDVFSNREG
     RLPSASGRTW READINYVSG FRNADRLVYS SDWLIYKTTD HYATFARIR