ID   RO21_XENLA              Reviewed;         346 AA.
AC   P51989;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Heterogeneous nuclear ribonucleoprotein A2 homolog 1;
DE   AltName: Full=hnRNP A2(A);
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8451200; DOI=10.1093/nar/21.4.999;
RA   Good P.J., Rebbert M.L., Dawid I.B.;
RT   "Three new members of the RNP protein family in Xenopus.";
RL   Nucleic Acids Res. 21:999-1006(1993).
CC   -!- FUNCTION: Forms complexes (ribonucleosomes) with at least 20 other
CC       different hnRNP and heterogeneous nuclear RNA in the nucleus.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Component of ribonucleosomes.
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DR   EMBL; L02954; AAA49948.1; -; mRNA.
DR   PIR; S40775; S40775.
DR   AlphaFoldDB; P51989; -.
DR   SMR; P51989; -.
DR   OMA; WGNNRQN; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   CDD; cd12762; RRM1_hnRNPA2B1; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034489; hnRNP_A2/B1.
DR   InterPro; IPR034486; hnRNPA2B1_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR48026:SF13; PTHR48026:SF13; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding.
FT   CHAIN           1..346
FT                   /note="Heterogeneous nuclear ribonucleoprotein A2 homolog
FT                   1"
FT                   /id="PRO_0000081822"
FT   DOMAIN          9..92
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          100..179
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          182..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          297..340
FT                   /note="Nuclear targeting sequence"
FT                   /evidence="ECO:0000250"
FT   REGION          326..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   346 AA;  36559 MW;  F7C8FE1F0CBB46D1 CRC64;
     MEREKEQFRK LFIGGLSFET TEESLRNYYE QWGTLTDCVV MRDPASKRSR GFGFVTFSCM
     NEVDAAMATR PHTIDGRVVE PKRAVAREES AKPGAHVTVK KLFVGGIKED TEEHHLREYF
     EEYGKIDSIE IITDKQSGKK RGFAFVTFDD HDPVDKIVLQ KYHTINGHNA EVRKALSKQE
     MQDVQNTRNN RGGNFGFGDS RGGGNFGSGP GGNFRGGSDG YGGGRGYGDN GYNGYGGGQG
     GGNYGGGPSY GGGRGGGYGG GAGYGNQGGG YGGGYDNYGG GNYGGGGNYN DFGNYNQQSS
     NYGPMKSGGN FGGNRSMGGG PYGGGNYGPG NASGGNGGGY GGRNRY