ID   RO22_XENLA              Reviewed;         358 AA.
AC   P51990; Q5D0C2;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Heterogeneous nuclear ribonucleoprotein A2 homolog 2;
DE   AltName: Full=hnRNP A2(B);
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
RX   PubMed=8451200; DOI=10.1093/nar/21.4.999;
RA   Good P.J., Rebbert M.L., Dawid I.B.;
RT   "Three new members of the RNP protein family in Xenopus.";
RL   Nucleic Acids Res. 21:999-1006(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms complexes (ribonucleosomes) with at least 20 other
CC       different hnRNP and heterogeneous nuclear RNA in the nucleus.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Component of ribonucleosomes.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P51990-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=P51990-2; Sequence=VSP_005823;
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DR   EMBL; L02955; AAB59951.1; -; mRNA.
DR   EMBL; BC043750; AAH43750.1; -; mRNA.
DR   PIR; S40776; S40776.
DR   RefSeq; NP_001079471.1; NM_001086002.1. [P51990-1]
DR   AlphaFoldDB; P51990; -.
DR   SMR; P51990; -.
DR   DNASU; 379158; -.
DR   GeneID; 379158; -.
DR   KEGG; xla:379158; -.
DR   CTD; 379158; -.
DR   Xenbase; XB-GENE-17340471; hnrnpa2b1.L.
DR   OMA; GCGGQGY; -.
DR   OrthoDB; 1202220at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 379158; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   CDD; cd12762; RRM1_hnRNPA2B1; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034489; hnRNP_A2/B1.
DR   InterPro; IPR034486; hnRNPA2B1_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR48026:SF13; PTHR48026:SF13; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Nucleus; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding.
FT   CHAIN           1..358
FT                   /note="Heterogeneous nuclear ribonucleoprotein A2 homolog
FT                   2"
FT                   /id="PRO_0000081823"
FT   DOMAIN          9..92
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          100..179
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          182..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..352
FT                   /note="Nuclear targeting sequence"
FT                   /evidence="ECO:0000250"
FT   REGION          333..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         241..252
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000303|PubMed:8451200"
FT                   /id="VSP_005823"
SQ   SEQUENCE   358 AA;  37929 MW;  F06233A5EBBFE663 CRC64;
     MEREKEQFRK LFIGGLSFET TEESLRNFYE QWGQLTDCVV MRDPASKRSR GFGFVTFSCM
     NEVDAAMSAR PHTIDGRVVE PKRAVAREES AKPGAHVTVK KLFVGGIKED TEEHHLREYF
     EEYGKIESTE IITDKQSGKK RGFGFVTFND HDPVDKIVLQ KYHTINGHNA EVRKALSKQE
     MQDVQNTRNN RGGNFGFGDS RGGGNFGSGP GGNFRGGSDG YGGGRGYGDG YNGYGGGQGG
     TYLDEKQNLY SSGNFGGGPS YGAGGGRGGY GGGPSYGNQG GGYGGGYDNY GGGNYGGGGN
     YNDFGNYNQQ SSSYGPMKSG GNFGGNRSMG GPYGGGNYGP GNGSGASGGG GYGGRNRY