ROA1_XENLA
ID ROA1_XENLA Reviewed; 365 AA.
AC P17130; P17131;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Heterogeneous nuclear ribonucleoproteins A1 homolog;
DE Short=hnRNP A1;
DE AltName: Full=Helix-destabilizing protein;
DE AltName: Full=Single-strand-binding protein;
DE AltName: Full=hnRNP core protein A1;
GN Name=hnrnpa1; Synonyms=hnrpa1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A1-A AND A1-B).
RX PubMed=2137612; DOI=10.1073/pnas.87.4.1367;
RA Kay B.K., Sawhney R.K., Wilson S.H.;
RT "Potential for two isoforms of the A1 ribonucleoprotein in Xenopus
RT laevis.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:1367-1371(1990).
CC -!- FUNCTION: This protein is a component of ribonucleosomes.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles continuously between the nucleus and the cytoplasm along
CC with mRNA. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A1-A;
CC IsoId=P17130-1; Sequence=Displayed;
CC Name=A1-B;
CC IsoId=P17130-2; Sequence=VSP_005826;
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DR EMBL; M31041; AAA49741.1; -; mRNA.
DR EMBL; M30575; AAA49742.1; -; mRNA.
DR PIR; A34840; A34840.
DR PIR; B34840; B34840.
DR AlphaFoldDB; P17130; -.
DR SMR; P17130; -.
DR Proteomes; UP000186698; Genome assembly.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd12761; RRM1_hnRNPA1; 1.
DR CDD; cd12580; RRM2_hnRNPA1; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR034845; hnRNPA1_RRM1.
DR InterPro; IPR034803; hnRNPA1_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW Ribonucleoprotein; RNA-binding.
FT CHAIN 1..365
FT /note="Heterogeneous nuclear ribonucleoproteins A1 homolog"
FT /id="PRO_0000081832"
FT DOMAIN 14..97
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 105..184
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 4..94
FT /note="Globular A domain"
FT REGION 95..185
FT /note="Globular B domain"
FT REGION 175..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..359
FT /note="Nuclear targeting sequence"
FT /evidence="ECO:0000250"
FT REGION 328..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 347..365
FT /note="GYGGGSASSSSGYGGGRRF -> EYPST (in isoform A1-B)"
FT /evidence="ECO:0000303|PubMed:2137612"
FT /id="VSP_005826"
SQ SEQUENCE 365 AA; 38317 MW; 7E61D3C4D1876B4F CRC64;
MHKSEAPNEP EQLRKLFIGG LSFETTDESL REHFEQWGTL TDCVVMRDPN SKRSRGFGFV
TYLSTDEVDA AMTARPHKVD GRVVEPKRAV SREDSSRPGA HLTVKKIFVG GIKEDTEEDH
LREYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFEDHDSVD KIVIQKYHTV NNHNSQVRKA
LSKQEMASVS GSQRERGGSG NYGSRGGFGN DNFGGRGGNF GGNRGGGGGF GNRGYGGDGY
NGDGQLWWQP SLLGWNRGYG AGQGGGYGAG QGGGYGGGGQ GGGYGGNGGY DGYNGGGSGF
SGSGGNFGSS GGYNDFGNYN SQSSSNFGPM KGGNYGGGRN SGPYGGGYGG GSASSSSGYG
GGRRF
