ROC11_DICDI
ID ROC11_DICDI Reviewed; 1487 AA.
AC Q6XHA5; Q55EL5;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Probable serine/threonine-protein kinase roco11;
DE EC=2.7.11.1;
DE AltName: Full=Ras of complex proteins and C-terminal of roc 11;
GN Name=roco11; ORFNames=DDB_G0268636;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14654223; DOI=10.1016/j.bbamcr.2003.08.008;
RA Bosgraaf L., van Haastert P.J.M.;
RT "Roc, a Ras/GTPase domain in complex proteins.";
RL Biochim. Biophys. Acta 1643:5-10(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. ROCO subfamily. {ECO:0000305}.
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DR EMBL; AY232273; AAO83656.1; -; Genomic_DNA.
DR EMBL; AAFI02000004; EAL72907.1; -; Genomic_DNA.
DR RefSeq; XP_647005.1; XM_641913.1.
DR AlphaFoldDB; Q6XHA5; -.
DR SMR; Q6XHA5; -.
DR STRING; 44689.DDB0191297; -.
DR PaxDb; Q6XHA5; -.
DR EnsemblProtists; EAL72907; EAL72907; DDB_G0268636.
DR GeneID; 8616698; -.
DR KEGG; ddi:DDB_G0268636; -.
DR dictyBase; DDB_G0268636; roco11.
DR eggNOG; KOG0192; Eukaryota.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_002809_0_0_1; -.
DR InParanoid; Q6XHA5; -.
DR PhylomeDB; Q6XHA5; -.
DR PRO; PR:Q6XHA5; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0036360; P:sorocarp stalk morphogenesis; IMP:dictyBase.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032171; COR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51424; ROC; 1.
PE 3: Inferred from homology;
KW ATP-binding; GTP-binding; Kinase; Leucine-rich repeat; Nucleotide-binding;
KW Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..1487
FT /note="Probable serine/threonine-protein kinase roco11"
FT /id="PRO_0000358897"
FT REPEAT 295..316
FT /note="LRR 1"
FT REPEAT 318..340
FT /note="LRR 2"
FT REPEAT 341..362
FT /note="LRR 3"
FT DOMAIN 379..564
FT /note="Roc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00758"
FT DOMAIN 1185..1452
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 108..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..564
FT /note="Small GTPase-like"
FT REGION 891..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1313
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 392..399
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00758"
FT BINDING 448..452
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00758"
FT BINDING 507..510
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00758"
FT BINDING 1191..1199
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 1216
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 1487 AA; 168497 MW; EB5CD8F6D89F408B CRC64;
METSQIRNGF NKVEVDVVGP LKDLLVRVMK NINTPFKILN ETFKINYCDQ QETKTKSSFY
IQTLDANDKS SLELTKSAIK NIQMQQQQQQ QQQQQQQQQQ HHDIFQFTQP SSSHNHSNHH
HHHHQQQLQQ QQQQQLQQQM KTPKLLFFIV MSVGVGKSYI KNIKEEAGTI PILEWFTNYI
RSWEEVFKLT SNQVTSHIKR QLLTKACTTG NINLLDEILL SGISKEQIKE TQTIGHGIIL
KSLIVNNLDS IVVSGSMSLL GAVIDNDNDK KGSSLILSKL NLNLFPKSII TACFNLAELD
LSYNNIKEIP KEICQLKHLK ILNMNNNQLD DLPLELANLT NLKYLAVQDN PLNKFPHHII
EQGTKRTLVF LKNIIEGKKS ETWNKVKLMF VGQEGVGKSS LCKALMGSRR RSSSSFAAEL
QKSGDTISTE GVKIQSIKGK KIDFYAWDFG GQQVFYPTHQ FFLTNQALYL LVFKLTDPNF
AERVNYWTLQ IKANSGLSVP MIFLVGTHCD ACTPEQLSSA EQILKENFVK YSRIRQNAIS
FVSCTNGTGI KELKKILTNE AEKSNLIKSN IPGSYLILEQ RLTDRGANSS RILINQNNIN
QNNNNNNNNN NHNNCNNNEN CTTTAATAGT TTMTSTTTTT TNYSNENILN TSSNSLIALF
TRSNSNSNLS NNYQKPLVNQ KYIDYNDFER ECKLSHLAQE EIQGATEFLH NMGIILHYDT
PILRSLVVLD PQWLADVMSS LITFSHNWIK NGILNHSELV SIWSGKYDQS IWPSLLKLLE
KFEVSYELPN EFPSRSLIPS LLPEEPIDRI QEIKEKLWIP LPEAIESKRV QIFGCQYNFD
FMPLGFFPRL LLRILLIKGI DIKTYWANGI LLDILTTEDI KIQKLNHKKH SILPNNSSST
SSSTSSSTSS STSSSSSSST SSSSTSTTTT TVQIQSSPFG NSTTIVNKLT NIDNNNNNNN
NNNNNNNNNN NINNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNIKNI INNFENQNNL
NNIITNNFGG KFEIIKKNDF ESPLSSKKPK HQVLVTFKNQ KSFESKDKDT YKLNVEIRSF
NVSNNNDKDF LASLFFQQLL STIDTLLSGS YGGLKVTRLI PCIHCIEKDP HSEPHLFDIN
SCISQLLLGK SQLVCGKDST TPVRIDYIAP DLSIKKIPIL LEDQVVCEEQ IGVGGFGLVH
KGKLILQDKS LVVAIKSYIV GNSSASDIIR KFQEFHHEMY IMSSLNHLNI VKLFGSMQNP
PRMVMEFAPH GDLYHFLEKK KNIKWSFKVR LMLDIAKGIE YLQNQNPPIV HRDLRSPNIF
LFSLDENAPV CAKVADFGLS QQSLYSVSGL LGNFQWMAPE TIGAEESYTE KIDTYSFSMI
LFTILTGECP FDEFTSFGKM EFIRKIREED LRPTIPSDCP PTISNLIELC WSGDPKKRPH
FSYIVKELTN FYYNLNLSPI PEQKSINDKS PHPDLISNGV PKLQIAK
