ROC4_ORYSJ
ID ROC4_ORYSJ Reviewed; 813 AA.
AC Q7Y0V9; Q7XUB3;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Homeobox-leucine zipper protein ROC4;
DE AltName: Full=GLABRA 2-like homeobox protein 4;
DE AltName: Full=HD-ZIP protein ROC4;
DE AltName: Full=Homeodomain transcription factor ROC4;
DE AltName: Full=Protein RICE OUTERMOST CELL-SPECIFIC 4;
GN Name=ROC4; Synonyms=GL2-4; OrderedLocusNames=Os04g0569100, LOC_Os04g48070;
GN ORFNames=OSJNBb0032E06.7;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Ito M., Sentoku N., Nishimura A., Hong S.-K., Sato Y., Matsuoka M.;
RT "The roles of rice GL2-type homeobox genes in epidermis differentiation.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Y0V9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Y0V9-2; Sequence=VSP_033316;
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class IV subfamily.
CC {ECO:0000305}.
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DR EMBL; AB101647; BAC77157.1; -; mRNA.
DR EMBL; AL663003; CAD41424.2; -; Genomic_DNA.
DR EMBL; AP008210; BAF15509.1; -; Genomic_DNA.
DR EMBL; AP014960; BAS90557.1; -; Genomic_DNA.
DR EMBL; AK112099; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015637147.1; XM_015781661.1. [Q7Y0V9-2]
DR AlphaFoldDB; Q7Y0V9; -.
DR SMR; Q7Y0V9; -.
DR STRING; 4530.OS04T0569100-01; -.
DR PaxDb; Q7Y0V9; -.
DR PRIDE; Q7Y0V9; -.
DR EnsemblPlants; Os04t0569100-01; Os04t0569100-01; Os04g0569100. [Q7Y0V9-2]
DR EnsemblPlants; Os04t0569100-02; Os04t0569100-02; Os04g0569100. [Q7Y0V9-1]
DR GeneID; 4336705; -.
DR Gramene; Os04t0569100-01; Os04t0569100-01; Os04g0569100. [Q7Y0V9-2]
DR Gramene; Os04t0569100-02; Os04t0569100-02; Os04g0569100. [Q7Y0V9-1]
DR KEGG; osa:4336705; -.
DR eggNOG; ENOG502QUAY; Eukaryota.
DR HOGENOM; CLU_015002_2_1_1; -.
DR InParanoid; Q7Y0V9; -.
DR OMA; GADHKMG; -.
DR OrthoDB; 226429at2759; -.
DR Proteomes; UP000000763; Chromosome 4.
DR Proteomes; UP000059680; Chromosome 4.
DR Genevisible; Q7Y0V9; OS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR042160; GLABRA2/ANL2/PDF2/ATML1-like.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR45654; PTHR45654; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF01852; START; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50848; START; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..813
FT /note="Homeobox-leucine zipper protein ROC4"
FT /id="PRO_0000331741"
FT DOMAIN 306..559
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT DNA_BIND 104..163
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 62..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 152..191
FT /evidence="ECO:0000255"
FT VAR_SEQ 431..437
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_033316"
FT CONFLICT 220
FT /note="L -> P (in Ref. 6; AK112099)"
FT /evidence="ECO:0000305"
FT CONFLICT 461
FT /note="K -> R (in Ref. 6; AK112099)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 813 AA; 86758 MW; 0E3934C3C9FAC70F CRC64;
MQFPFSGAGP GVFTSSPALS LALADAVAGR NSGGGGKMVT AAHGGVGGGG GGGRAKARDA
LEVENEMSRS GSDHLDVVSC GDAGGGGGDD DDDEDAEHGN PPKRKKRYHR HTPQQIQELE
AMFKECPHPD EKQRAELSKR LGLEPRQVKF WFQNRRTQMK MQLERHENSL LKQENDKLRS
ENLSIREATS NAVCVGCGGP AMLGEVSLEE HHLRVENARL KDELSRVCAL AAKFLGKSIS
VMAPPQMHQP HPVPGSSLEL AVGGIGSMPS ATMPISTITD FAGAMSSSMG TVITPMKSEA
EPSAMAGIDK SLFLELAMSA MDELVKMAQM GDPLWIPGAS VPSSPAKESL NFEEYLNTFP
PCIGVKPEGY VSEASRESGI VIIDDGAALV ETLMDERRWS DMFSCMIAKA STTEEISTGV
AGSRNGALLL VSDEHSVMQA ELQVLSPLVP IREVKFLRFS KQLADGVWAV VDVSADELMR
DQGITSASST ANMNCRRLPS GCVLQDTPNG FVKVTWVEHT EYDEASVHPL YRPLLRSGLA
LGAGRWIATL QRQCECLALL MSSIALPEND SSAIHPEGKR SMLKLARRMT DNFCAGVSTS
STREWSKLVG LTGNIGEDVH VMARKSVDEP GTPPGVVLSA ATSVWMPVMP ERLFNFLHNK
GLRAEWDILS NGGPMQEVTS IAKGQQNGNT VCLLKASPTK DKQNSMLILQ ETCADASGSM
VVYAPVDIPA MHLVMSGGDS SCVALLPSGF AILPAGPSIG ADHKMGGSLL TVAFQILANS
QPSAKLTVES VETVSNLISC TIKKIKTALH CDV
