ID   AB27_CYPCA              Reviewed;          19 AA.
AC   P81925;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=27 kDa antibacterial protein;
DE   Flags: Fragment;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Skin mucus;
RX   PubMed=8797847; DOI=10.1111/j.1432-1033.1996.0143h.x;
RA   Lemaitre C., Orange N., Saglio P., Saint N., Gagnon J., Molle G.;
RT   "Characterization and ion channel activities of novel antibacterial
RT   proteins from the skin mucosa of carp (Cyprinus carpio).";
RL   Eur. J. Biochem. 240:143-149(1996).
CC   -!- FUNCTION: Has antibacterial activity. It inhibits fish bacterial
CC       pathogens, A.hydrophila and M.luteus, and also E.coli, P.fluorescens
CC       and S.aureus. Forms large ion channels responsible for disrupting the
CC       cellular envelope of bacteria leading to cell lysis.
CC       {ECO:0000269|PubMed:8797847, ECO:0000305}.
CC   -!- PTM: Glycosylated. {ECO:0000305}.
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DR   PIR; S74087; S74087.
DR   AlphaFoldDB; P81925; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; TAS:UniProtKB.
DR   GO; GO:0045161; P:neuronal ion channel clustering; TAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing;
KW   Glycoprotein; Reference proteome.
FT   CHAIN           1..>19
FT                   /note="27 kDa antibacterial protein"
FT                   /id="PRO_0000064420"
FT   NON_TER         19
SQ   SEQUENCE   19 AA;  1966 MW;  6DC0EA343D6F0242 CRC64;
     GIGGKPVQTA FVDNDGIYD