RODL_ASPFU
ID RODL_ASPFU Reviewed; 159 AA.
AC P41746; Q4WUT3;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Hydrophobin;
DE AltName: Full=Rodlet protein;
DE Flags: Precursor;
GN Name=rodA; Synonyms=hyp1; ORFNames=AFUA_5G09580;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CHUV 192-88;
RX PubMed=7927699; DOI=10.1128/iai.62.10.4380-4388.1994;
RA Thau N., Monod M., Crestani B., Rolland C., Tronchin G., Latge J.-P.,
RA Paris S.;
RT "Rodletless mutants of Aspergillus fumigatus.";
RL Infect. Immun. 62:4380-4388(1994).
RN [2]
RP ERRATUM OF PUBMED:7927699.
RA Thau N., Monod M., Crestani B., Rolland C., Tronchin G., Latge J.-P.,
RA Paris S.;
RL Infect. Immun. 62:5706-5706(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=B-5233;
RX PubMed=7927700; DOI=10.1128/iai.62.10.4389-4395.1994;
RA Parta M., Chang Y., Rulong S., Pinto-Dasilva P., Kwon-Chung K.J.;
RT "HYP1, a hydrophobin gene from Aspergillus fumigatus, complements the
RT rodletless phenotype in Aspergillus nidulans.";
RL Infect. Immun. 62:4389-4395(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Cell wall protein regularly arranged in interwoven fascicules
CC of clustered proteinaceous microfibrils, or rodlets, to form the outer
CC spore coat protein. It is involved in resistance to environmental
CC stress and may well be associated with conidial hydrophobicity. It is
CC important in the morphogenesis of the dispersible conidia.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall.
CC -!- DEVELOPMENTAL STAGE: Expression is limited to the developmental stages
CC in which maturing conidiophores are present.
CC -!- SIMILARITY: Belongs to the fungal hydrophobin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U06121; AAB60712.1; -; Genomic_DNA.
DR EMBL; L25258; AAB07707.1; -; Genomic_DNA.
DR EMBL; AAHF01000003; EAL91643.1; -; Genomic_DNA.
DR RefSeq; XP_753681.1; XM_748588.1.
DR AlphaFoldDB; P41746; -.
DR SMR; P41746; -.
DR STRING; 746128.CADAFUBP00005595; -.
DR SwissPalm; P41746; -.
DR GeneID; 3511423; -.
DR KEGG; afm:AFUA_5G09580; -.
DR eggNOG; ENOG502T10M; Eukaryota.
DR HOGENOM; CLU_106380_1_0_1; -.
DR InParanoid; P41746; -.
DR OrthoDB; 1513191at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0009277; C:fungal-type cell wall; IEA:InterPro.
DR GO; GO:0005199; F:structural constituent of cell wall; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR001338; Hydrophobin.
DR InterPro; IPR019778; Hydrophobin_CS.
DR Pfam; PF01185; Hydrophobin; 1.
DR SMART; SM00075; HYDRO; 1.
DR PROSITE; PS00956; HYDROPHOBIN; 1.
PE 2: Evidence at transcript level;
KW Cell wall; Cell wall biogenesis/degradation; Conidiation; Disulfide bond;
KW Reference proteome; Secreted; Signal; Sporulation.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..159
FT /note="Hydrophobin"
FT /id="PRO_0000013506"
FT DISULFID 56..133
FT /evidence="ECO:0000250"
FT DISULFID 64..127
FT /evidence="ECO:0000250"
FT DISULFID 65..105
FT /evidence="ECO:0000250"
FT DISULFID 134..152
FT /evidence="ECO:0000250"
FT CONFLICT 107..108
FT /note="KL -> NV (in Ref. 1; AAB60712)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="V -> I (in Ref. 4; EAL91643)"
FT /evidence="ECO:0000305"
FT CONFLICT 121
FT /note="A -> D (in Ref. 4; EAL91643)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 16112 MW; 125D10704052A8BE CRC64;
MKFSLSAAVL AFAVSVAALP QHDVNAAGNG VGNKGNANVR FPVPDDITVK QATEKCGDQA
QLSCCNKATY AGDVTDIDEG ILAGTLKNLI GGGSGTEGLG LFNQCSKLDL QIPVIGIPIQ
ALVNQKCKQN IACCQNSPSD ASGSLIGLGL PCIALGSIL
