ROFG6_ARATH
ID ROFG6_ARATH Reviewed; 579 AA.
AC Q9M056;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Rop guanine nucleotide exchange factor 6;
DE Short=AtRopGEF6;
DE AltName: Full=Rho of plants guanine nucleotide exchange factor 6;
GN Name=ROPGEF6; OrderedLocusNames=At3g55660; ORFNames=F1I16.70;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clone.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=15980860; DOI=10.1038/nature03883;
RA Berken A., Thomas C., Wittinghofer A.;
RT "A new family of RhoGEFs activates the Rop molecular switch in plants.";
RL Nature 436:1176-1180(2005).
CC -!- FUNCTION: Guanine-nucleotide exchange factor (GEF) that acts as an
CC activator of Rop (Rho of plants) GTPases by promoting the exchange of
CC GDP for GTP. {ECO:0000250}.
CC -!- DOMAIN: The PRONE (plant-specific Rop nucleotide exchanger) domain is
CC responsible for the GEF activity. {ECO:0000250}.
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DR EMBL; AL161667; CAB81591.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79417.1; -; Genomic_DNA.
DR EMBL; BT020279; AAV84500.1; -; mRNA.
DR EMBL; BT021117; AAX12887.1; -; mRNA.
DR PIR; T47705; T47705.
DR RefSeq; NP_191125.1; NM_115424.3.
DR AlphaFoldDB; Q9M056; -.
DR SMR; Q9M056; -.
DR STRING; 3702.AT3G55660.1; -.
DR PaxDb; Q9M056; -.
DR PRIDE; Q9M056; -.
DR EnsemblPlants; AT3G55660.1; AT3G55660.1; AT3G55660.
DR GeneID; 824732; -.
DR Gramene; AT3G55660.1; AT3G55660.1; AT3G55660.
DR KEGG; ath:AT3G55660; -.
DR Araport; AT3G55660; -.
DR TAIR; locus:2078976; AT3G55660.
DR eggNOG; ENOG502QPIY; Eukaryota.
DR HOGENOM; CLU_019073_2_0_1; -.
DR InParanoid; Q9M056; -.
DR OMA; FEGTEFW; -.
DR OrthoDB; 482824at2759; -.
DR PhylomeDB; Q9M056; -.
DR PRO; PR:Q9M056; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M056; baseline and differential.
DR Genevisible; Q9M056; AT.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:TAIR.
DR InterPro; IPR005512; PRONE_dom.
DR InterPro; IPR038937; RopGEF.
DR PANTHER; PTHR33101; PTHR33101; 1.
DR Pfam; PF03759; PRONE; 1.
DR PROSITE; PS51334; PRONE; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor; Reference proteome.
FT CHAIN 1..579
FT /note="Rop guanine nucleotide exchange factor 6"
FT /id="PRO_0000423892"
FT DOMAIN 98..479
FT /note="PRONE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00663"
FT REGION 31..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 64287 MW; 20A404671C4F8874 CRC64;
MEDNSCIGFE GSKRFGETSK RIIGLIDSVT ESTTDSSLSS SSSGVGSSSG RSSVAERSVS
SPPTKSQILG WPLGQGSWRK SSGKMKKKTP TKIDDFGFKR VGTETSEIEL LKERMAKLLL
GEDMSGSGEG VCPALAISNA ITNLYAAILG QQWRLEPIPS EKKLMWRREI EVLLSVSDHI
VELVPSFQNF PNGNKIEVMN CRPRSDLFTC LPALRKLDNM LIEILDSFGE TEFWYVDQGI
VAAESARSNS FREDGDKWWL PLPRVPSDGL TEQTRKKLDH TREFTNQILK ACMSINSIAL
AEMEVPQSYL EALPKNGRSC LGDFLYRNIT SDNFSADHLL ESIDLSSELA VVEMANRVEA
SMYVWRRRAH SRHLISLYRS TSTRWGMIVK EMMMHQTDGD KREIFAERAE SLLIRLKQRF
PGLRQTALDT SKIQYNKDVG KSILESYSRV LESLAYSIGV RIEEVLFMDD ISKDDGDGDD
DSCSDKLRLL SKEAASGGSG SLREKLSAPS LFSVSFSGTS TPYRTLSFSA STPSYSPMPL
ISPINGGRGG ERAPFLSGRN IRERCGFGPK KALANYLRG
