ROG1_YEAST
ID ROG1_YEAST Reviewed; 685 AA.
AC P53118; D6VU05; Q66RA3;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Putative lipase ROG1;
DE EC=3.1.-.-;
DE AltName: Full=Revertant of glycogen synthase kinase mutation protein 1;
GN Name=ROG1; OrderedLocusNames=YGL144C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9046099;
RX DOI=10.1002/(sici)1097-0061(199702)13:2<177::aid-yea62>3.0.co;2-2;
RA Voet M., Defoor E., Verhasselt P., Riles L., Robben J., Volckaert G.;
RT "The sequence of a nearly unclonable 22.8 kb segment on the left arm
RT chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1,
RT MRF1 genes and six new open reading frames.";
RL Yeast 13:177-182(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
CC -!- INTERACTION:
CC P53118; P43603: LSB3; NbExp=2; IntAct=EBI-24005, EBI-22980;
CC -!- SIMILARITY: Belongs to the putative lipase ROG1 family. {ECO:0000305}.
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DR EMBL; X99960; CAA68218.1; -; Genomic_DNA.
DR EMBL; Z72666; CAA96856.1; -; Genomic_DNA.
DR EMBL; AY723812; AAU09729.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07966.1; -; Genomic_DNA.
DR PIR; S64158; S64158.
DR RefSeq; NP_011371.1; NM_001181009.1.
DR AlphaFoldDB; P53118; -.
DR BioGRID; 33108; 72.
DR IntAct; P53118; 3.
DR MINT; P53118; -.
DR STRING; 4932.YGL144C; -.
DR ESTHER; yeast-ROG1; Duf_676.
DR MaxQB; P53118; -.
DR PaxDb; P53118; -.
DR PRIDE; P53118; -.
DR EnsemblFungi; YGL144C_mRNA; YGL144C; YGL144C.
DR GeneID; 852733; -.
DR KEGG; sce:YGL144C; -.
DR SGD; S000003112; ROG1.
DR VEuPathDB; FungiDB:YGL144C; -.
DR eggNOG; KOG4372; Eukaryota.
DR GeneTree; ENSGT00940000176402; -.
DR HOGENOM; CLU_007367_1_0_1; -.
DR InParanoid; P53118; -.
DR OMA; TIARRWH; -.
DR BioCyc; YEAST:G3O-30638-MON; -.
DR PRO; PR:P53118; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53118; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0047372; F:acylglycerol lipase activity; IDA:SGD.
DR GO; GO:0044255; P:cellular lipid metabolic process; IMP:SGD.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007751; DUF676_lipase-like.
DR InterPro; IPR044294; Lipase-like.
DR InterPro; IPR016445; Rog1_fam.
DR PANTHER; PTHR12482; PTHR12482; 2.
DR Pfam; PF05057; DUF676; 1.
DR PIRSF; PIRSF005412; UCP005412_abhydr; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00120; LIPASE_SER; 1.
PE 1: Evidence at protein level;
KW Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome.
FT CHAIN 1..685
FT /note="Putative lipase ROG1"
FT /id="PRO_0000202735"
FT ACT_SITE 269
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
FT CONFLICT 514
FT /note="F -> S (in Ref. 4; AAU09729)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 685 AA; 78142 MW; BE800C5E15148E4A CRC64;
MSLTPTNEIL FHYKSSVKVG ELERYVITYH LYDGEEIPPD LNLNSLWLKV RNMNPLSYRA
AYLMGPFMLY CDVKTAQYHH SQKIVASVDY PKFEPNVQTQ QDFVAELSVH NIRQKYVWIA
DVMSQILFTT NTNVTYEVTI GTSKESVENP HDLPSHLGSY SPKLTVNRLT TLDLWNLPVQ
ITTPQKKKHL VVLTHGLHSN VSTDLVYIME QIYKAQKNYP HEQIVVKGYR GNVCQTEKGV
KYLGTRLAEY IIQDLYDESI RKISFVGHSL GGLIQAFAIA YIYEVYPWFF KKVNPINFIT
LASPLLGIVT DNPAYIKVLL SFGVIGKTGQ DLGLENDVEV GKPLLYLLSG LPLIEILRRF
KRRTVYANAI NDGIVPLYTA SLLFLDYNDI LEQLQKLKEN SKKSPLINDA STPVNQDFFN
KTFISPLTKM LSILAPQKFP TENGSEIPKV SFFESASSIL LPPLPERAYI MDPDSRDPVI
IHDKIYNEDD IPQSEFDIED GFFGKKNILL QAFFAGKKER AKYRNLEETI ARRWHEGMAW
RKVVVALKPD AHNNIIVRRK FANAYGWPVI DHLIDVHFNG DDDDDNDEND DINSTQVVEP
IQSVTEGKKK YRKAENIPQE YGWLNKVETN GVFDEGPTGM ISTVGEIVEA LAKRGFSAVI
DRRNASEDPN DEVLRFEEMN SDLVQ
