ROGDI_MOUSE
ID ROGDI_MOUSE Reviewed; 287 AA.
AC Q3TDK6; Q8BL37; Q922N4; Q923H8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Protein rogdi homolog;
DE AltName: Full=Leucine-zipper-containing LZF;
GN Name=Rogdi; Synonyms=Lzf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=11740862; DOI=10.1006/excr.2001.5394;
RA Tulin E.E., Onoda N., Hasegawa M., Nosaka T., Nomura H., Kitamura T.;
RT "Genetic approach and phenotype-based complementation screening for
RT identification of stroma cell-derived proteins involved in cell
RT proliferation.";
RL Exp. Cell Res. 272:23-31(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q9GZN7}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:Q9GZN7}.
CC Presynapse {ECO:0000250|UniProtKB:Q4V7D2}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q4V7D2}. Perikaryon
CC {ECO:0000250|UniProtKB:Q4V7D2}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q4V7D2}. Cytoplasmic vesicle, secretory vesicle,
CC synaptic vesicle {ECO:0000250|UniProtKB:Q4V7D2}. Note=Detected
CC primarily at presynaptic sites on axons, and to a lesser degree in soma
CC and dendrites. Not detected at post-synaptic sites.
CC {ECO:0000250|UniProtKB:Q4V7D2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3TDK6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TDK6-2; Sequence=VSP_030600;
CC Name=3;
CC IsoId=Q3TDK6-3; Sequence=VSP_030601;
CC -!- TISSUE SPECIFICITY: Detected in brain, kidney and testis.
CC {ECO:0000269|PubMed:11740862}.
CC -!- SIMILARITY: Belongs to the rogdi family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK71345.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY036117; AAK71345.1; ALT_FRAME; mRNA.
DR EMBL; AK046477; BAC32748.1; -; mRNA.
DR EMBL; AK170144; BAE41595.1; -; mRNA.
DR EMBL; BC006914; AAH06914.1; -; mRNA.
DR CCDS; CCDS79419.1; -. [Q3TDK6-1]
DR RefSeq; NP_573448.2; NM_133185.2. [Q3TDK6-1]
DR AlphaFoldDB; Q3TDK6; -.
DR SMR; Q3TDK6; -.
DR BioGRID; 211177; 3.
DR IntAct; Q3TDK6; 3.
DR MINT; Q3TDK6; -.
DR STRING; 10090.ENSMUSP00000023191; -.
DR iPTMnet; Q3TDK6; -.
DR PhosphoSitePlus; Q3TDK6; -.
DR SwissPalm; Q3TDK6; -.
DR MaxQB; Q3TDK6; -.
DR PeptideAtlas; Q3TDK6; -.
DR PRIDE; Q3TDK6; -.
DR ProteomicsDB; 301640; -. [Q3TDK6-1]
DR ProteomicsDB; 301641; -. [Q3TDK6-2]
DR ProteomicsDB; 301642; -. [Q3TDK6-3]
DR Antibodypedia; 42735; 79 antibodies from 19 providers.
DR DNASU; 66049; -.
DR Ensembl; ENSMUST00000023191; ENSMUSP00000023191; ENSMUSG00000022540. [Q3TDK6-2]
DR Ensembl; ENSMUST00000090453; ENSMUSP00000087938; ENSMUSG00000022540. [Q3TDK6-3]
DR Ensembl; ENSMUST00000202281; ENSMUSP00000144481; ENSMUSG00000022540. [Q3TDK6-1]
DR GeneID; 66049; -.
DR KEGG; mmu:66049; -.
DR UCSC; uc007ybj.1; mouse. [Q3TDK6-1]
DR CTD; 79641; -.
DR MGI; MGI:1913299; Rogdi.
DR VEuPathDB; HostDB:ENSMUSG00000022540; -.
DR eggNOG; KOG3992; Eukaryota.
DR GeneTree; ENSGT00390000007164; -.
DR HOGENOM; CLU_062094_1_0_1; -.
DR InParanoid; Q3TDK6; -.
DR OMA; NILMECA; -.
DR OrthoDB; 1051737at2759; -.
DR PhylomeDB; Q3TDK6; -.
DR TreeFam; TF105859; -.
DR BioGRID-ORCS; 66049; 2 hits in 65 CRISPR screens.
DR ChiTaRS; Rogdi; mouse.
DR PRO; PR:Q3TDK6; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q3TDK6; protein.
DR Bgee; ENSMUSG00000022540; Expressed in retinal neural layer and 258 other tissues.
DR ExpressionAtlas; Q3TDK6; baseline and differential.
DR Genevisible; Q3TDK6; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0005635; C:nuclear envelope; ISO:MGI.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; ISO:MGI.
DR GO; GO:0043291; C:RAVE complex; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0007420; P:brain development; ISO:MGI.
DR GO; GO:0030097; P:hemopoiesis; IDA:MGI.
DR GO; GO:0022008; P:neurogenesis; ISO:MGI.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:MGI.
DR InterPro; IPR028241; RAVE2/Rogdi.
DR PANTHER; PTHR13618; PTHR13618; 1.
DR Pfam; PF10259; Rogdi_lz; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell projection; Cytoplasmic vesicle;
KW Nucleus; Reference proteome; Synapse.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9GZN7"
FT CHAIN 2..287
FT /note="Protein rogdi homolog"
FT /id="PRO_0000315665"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9GZN7"
FT VAR_SEQ 85
FT /note="A -> ALPPGWLRRLGPQPSPHCIAGSQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030600"
FT VAR_SEQ 205..287
FT /note="QLHALQPTSTKNFRPAGGAVLHSPGAMFEWGSQRLEVSHVHKVECVIPWLND
FT ALVYFTVSLQLCQQLKDKIAVFSSYWSSRPF -> HLFCDPTHL (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030601"
FT CONFLICT 158
FT /note="S -> N (in Ref. 1; AAK71345)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="A -> T (in Ref. 1; AAK71345)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="Y -> H (in Ref. 2; BAE41595)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 287 AA; 32100 MW; 5F47C4A8073B1A04 CRC64;
MATAMAASAA ERAVLEEEFR WLLHAEVHAV LRQLQDILKE ASLRFTLPGP STEGPAKQEN
FILGSCGTDQ VKGTLTLQGD ALSQADVNLK MPRNNQLLHL AFREDKQWKL QQIQDARNHV
SQAIYLLANR DESYQFKTGA EVLKLMDAVM LQLTRARSRL TTPATLTLPE IAASGLTRMF
APTLPSDLLV NVYINLNKLC LTVYQLHALQ PTSTKNFRPA GGAVLHSPGA MFEWGSQRLE
VSHVHKVECV IPWLNDALVY FTVSLQLCQQ LKDKIAVFSS YWSSRPF
