ROGF2_ARATH
ID ROGF2_ARATH Reviewed; 485 AA.
AC Q9LQ89;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Rop guanine nucleotide exchange factor 2;
DE Short=AtRopGEF2;
DE AltName: Full=Rho of plants guanine nucleotide exchange factor 2;
GN Name=ROPGEF2; OrderedLocusNames=At1g01700; ORFNames=T1N6.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP CHARACTERIZATION, FUNCTION, AND GENE FAMILY.
RX PubMed=15980860; DOI=10.1038/nature03883;
RA Berken A., Thomas C., Wittinghofer A.;
RT "A new family of RhoGEFs activates the Rop molecular switch in plants.";
RL Nature 436:1176-1180(2005).
RN [4]
RP INTERACTION WITH ARAC10/ROP11, AND TISSUE SPECIFICITY.
RX PubMed=22500990; DOI=10.1016/j.febslet.2012.03.040;
RA Li Z., Liu D.;
RT "ROPGEF1 and ROPGEF4 are functional regulators of ROP11 GTPase in ABA-
RT mediated stomatal closure in Arabidopsis.";
RL FEBS Lett. 586:1253-1258(2012).
CC -!- FUNCTION: Guanine-nucleotide exchange factor (GEF) that acts as an
CC activator of Rop (Rho of plants) GTPases by promoting the exchange of
CC GDP for GTP. {ECO:0000269|PubMed:15980860}.
CC -!- SUBUNIT: Interacts with ARC10/ROP11. {ECO:0000269|PubMed:22500990}.
CC -!- TISSUE SPECIFICITY: Expressed in the vascular tissues of roots, leaves,
CC sepals, petals and siliques. {ECO:0000269|PubMed:22500990}.
CC -!- DOMAIN: The PRONE (plant-specific Rop nucleotide exchanger) domain is
CC responsible for the GEF activity. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF78400.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009273; AAF78400.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27324.1; -; Genomic_DNA.
DR PIR; A86148; A86148.
DR RefSeq; NP_171676.1; NM_100052.2.
DR AlphaFoldDB; Q9LQ89; -.
DR SMR; Q9LQ89; -.
DR BioGRID; 24485; 2.
DR IntAct; Q9LQ89; 1.
DR MINT; Q9LQ89; -.
DR STRING; 3702.AT1G01700.1; -.
DR PaxDb; Q9LQ89; -.
DR PRIDE; Q9LQ89; -.
DR EnsemblPlants; AT1G01700.1; AT1G01700.1; AT1G01700.
DR GeneID; 839250; -.
DR Gramene; AT1G01700.1; AT1G01700.1; AT1G01700.
DR KEGG; ath:AT1G01700; -.
DR Araport; AT1G01700; -.
DR TAIR; locus:2198220; AT1G01700.
DR eggNOG; ENOG502QV6R; Eukaryota.
DR HOGENOM; CLU_019073_4_1_1; -.
DR InParanoid; Q9LQ89; -.
DR PhylomeDB; Q9LQ89; -.
DR PRO; PR:Q9LQ89; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LQ89; baseline and differential.
DR Genevisible; Q9LQ89; AT.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:TAIR.
DR InterPro; IPR005512; PRONE_dom.
DR InterPro; IPR038937; RopGEF.
DR PANTHER; PTHR33101; PTHR33101; 1.
DR Pfam; PF03759; PRONE; 1.
DR PROSITE; PS51334; PRONE; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor; Reference proteome.
FT CHAIN 1..485
FT /note="Rop guanine nucleotide exchange factor 2"
FT /id="PRO_0000234059"
FT DOMAIN 107..485
FT /note="PRONE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00663"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 54699 MW; E7C2574C8810E4EA CRC64;
MENLPNHEEN DDVGYHQSPG PIDPNDHSAS ETPVYSTMST DSFAYHRTCS ETSGGGFSDQ
IDETSSFCTE ASPSDWPVLT ESNNSASSNF PTVFDLKHNQ IETDEHLAVQ EISEPELETM
KERFSKLLLG EDMSGSGKGV CTAVTISNAI TNLYATVFGQ NLRLEPLEIE QKTTWKREMN
CLLSVCDYIF EFIPKSQNLS NGATVEVMES RPRADIYINL PALRKLDSML MEALDSFQKT
EFWYAEEGSL SMKSTRSATG SFRKVIVQRK EEKWWLPIPL VPLQGLSEKA RKQLKSKRES
TNQIHKAAMA INSSILGEMD IPDSYMATLP KSGKASTGDA IYRHMTSSGR FSPEKLLDRL
KIVSEHEALQ LADRVEASMY TWRRKACLNN SKSSWNMVKD LMSITERSDK NYVLAERAES
LLFCLKQRYP ELSQTSLDIC KIHCNKDVGK AVLESYSRVL EGLAFNIVAW IDDVLYVDKT
MRGEE
