ROGF3_ARATH
ID ROGF3_ARATH Reviewed; 473 AA.
AC A4IJ27; O23056; O65256; Q9M163;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Rop guanine nucleotide exchange factor 3;
DE Short=AtRopGEF3;
DE AltName: Full=Rho of plants guanine nucleotide exchange factor 3;
GN Name=ROPGEF3; OrderedLocusNames=At4g00460; ORFNames=F5I10.1, F6N23.23;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Bautista V.R., Chen H., De Los Reyes C., Wu S.Y., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY.
RX PubMed=15980860; DOI=10.1038/nature03883;
RA Berken A., Thomas C., Wittinghofer A.;
RT "A new family of RhoGEFs activates the Rop molecular switch in plants.";
RL Nature 436:1176-1180(2005).
CC -!- FUNCTION: Guanine-nucleotide exchange factor (GEF) that acts as an
CC activator of Rop (Rho of plants) GTPases by promoting the exchange of
CC GDP for GTP. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=A4IJ27-1; Sequence=Displayed;
CC -!- DOMAIN: The PRONE (plant-specific Rop nucleotide exchanger) domain is
CC responsible for the GEF activity. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB62823.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAC13624.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAF02781.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80855.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80856.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF013293; AAB62823.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF058919; AAC13624.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AF195115; AAF02781.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161472; CAB80855.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161472; CAB80856.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE81885.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66275.1; -; Genomic_DNA.
DR EMBL; BT030385; ABO45688.1; -; mRNA.
DR PIR; G85006; G85006.
DR PIR; T01211; T01211.
DR PIR; T01525; T01525.
DR RefSeq; NP_001118903.1; NM_001125431.2. [A4IJ27-1]
DR RefSeq; NP_001328183.1; NM_001340253.1. [A4IJ27-1]
DR AlphaFoldDB; A4IJ27; -.
DR SMR; A4IJ27; -.
DR STRING; 3702.AT4G00460.2; -.
DR PaxDb; A4IJ27; -.
DR PRIDE; A4IJ27; -.
DR ProteomicsDB; 228215; -. [A4IJ27-1]
DR DNASU; 827967; -.
DR EnsemblPlants; AT4G00460.2; AT4G00460.2; AT4G00460. [A4IJ27-1]
DR EnsemblPlants; AT4G00460.4; AT4G00460.4; AT4G00460. [A4IJ27-1]
DR GeneID; 827967; -.
DR Gramene; AT4G00460.2; AT4G00460.2; AT4G00460. [A4IJ27-1]
DR Gramene; AT4G00460.4; AT4G00460.4; AT4G00460. [A4IJ27-1]
DR KEGG; ath:AT4G00460; -.
DR Araport; AT4G00460; -.
DR TAIR; locus:2126071; AT4G00460.
DR eggNOG; ENOG502QV6R; Eukaryota.
DR HOGENOM; CLU_019073_4_1_1; -.
DR InParanoid; A4IJ27; -.
DR OMA; HMYSAEK; -.
DR OrthoDB; 482824at2759; -.
DR PhylomeDB; A4IJ27; -.
DR PRO; PR:A4IJ27; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; A4IJ27; baseline and differential.
DR Genevisible; A4IJ27; AT.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:TAIR.
DR InterPro; IPR005512; PRONE_dom.
DR InterPro; IPR038937; RopGEF.
DR PANTHER; PTHR33101; PTHR33101; 1.
DR Pfam; PF03759; PRONE; 1.
DR PROSITE; PS51334; PRONE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Guanine-nucleotide releasing factor;
KW Reference proteome.
FT CHAIN 1..473
FT /note="Rop guanine nucleotide exchange factor 3"
FT /id="PRO_0000423889"
FT DOMAIN 95..473
FT /note="PRONE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00663"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 53533 MW; 70620A4F04923C18 CRC64;
MENLSNPDEN DDHQSPRSID QNDQSAVETP VYSTMSIDSF VYPRTCSETT SGFSDQIDET
NSFCSEASPC NWPVLTESKS SKCLSGLEMQ SNECLVVQEI SEPELETMKE RFAKLLLGED
MSGSGKGVCT AVTISNAITN LYATVFGQNL RLEPLETEKR ALWKREMNCL LSVCDYIVEF
IPRCQNLSNG ATVEVMESRP RADIYINLPA LRKLDSMLME ALDSFQNTEF WYAEEGSLSM
KSARSSTGSF RKVIVQRKEE KWWLPVPLVP SEGLSDKARK QLKNKRESTN QIHKAAMAIN
SSILSEMEIP DSYMTTLPKC GKSSVGDSIY RYMSGSGRFF PEQLLDCLNI SSEHEAVQLA
DRVEASMYTW RRKSCLSNSK NSWNMVKDLM STTERTDKNY VMAERAETLL FCLKQRYPEL
SQTSLDICKI QYNKDVGKAV LESYSRVLEG LAFNIVAWID DVLYVDKTMR GSE
