ID   ROGF5_ARATH             Reviewed;         611 AA.
AC   F4K295; Q9FI92;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Rop guanine nucleotide exchange factor 5;
DE            Short=AtRopGEF5;
DE   AltName: Full=Rho of plants guanine nucleotide exchange factor 5;
GN   Name=ROPGEF5; OrderedLocusNames=At5g05940;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA   Miyajima N., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT   features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT   clones.";
RL   DNA Res. 6:183-195(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14993207; DOI=10.1101/gr.1515604;
RA   Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA   Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA   Weissenbach J., Salanoubat M.;
RT   "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT   combined approach to evaluate and improve Arabidopsis genome annotation.";
RL   Genome Res. 14:406-413(2004).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=15980860; DOI=10.1038/nature03883;
RA   Berken A., Thomas C., Wittinghofer A.;
RT   "A new family of RhoGEFs activates the Rop molecular switch in plants.";
RL   Nature 436:1176-1180(2005).
CC   -!- FUNCTION: Guanine-nucleotide exchange factor (GEF) that acts as an
CC       activator of Rop (Rho of plants) GTPases by promoting the exchange of
CC       GDP for GTP. {ECO:0000250}.
CC   -!- DOMAIN: The PRONE (plant-specific Rop nucleotide exchanger) domain is
CC       responsible for the GEF activity. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB10799.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BX832060; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB017060; BAB10799.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED90943.1; -; Genomic_DNA.
DR   EMBL; BX832060; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_196213.2; NM_120676.3.
DR   AlphaFoldDB; F4K295; -.
DR   SMR; F4K295; -.
DR   STRING; 3702.AT5G05940.1; -.
DR   PaxDb; F4K295; -.
DR   PRIDE; F4K295; -.
DR   ProteomicsDB; 227985; -.
DR   EnsemblPlants; AT5G05940.1; AT5G05940.1; AT5G05940.
DR   GeneID; 830479; -.
DR   Gramene; AT5G05940.1; AT5G05940.1; AT5G05940.
DR   KEGG; ath:AT5G05940; -.
DR   Araport; AT5G05940; -.
DR   TAIR; locus:2153684; AT5G05940.
DR   eggNOG; ENOG502QPIY; Eukaryota.
DR   HOGENOM; CLU_019073_2_0_1; -.
DR   InParanoid; F4K295; -.
DR   OrthoDB; 383472at2759; -.
DR   PRO; PR:F4K295; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4K295; baseline and differential.
DR   Genevisible; F4K295; AT.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:TAIR.
DR   InterPro; IPR005512; PRONE_dom.
DR   InterPro; IPR038937; RopGEF.
DR   PANTHER; PTHR33101; PTHR33101; 1.
DR   Pfam; PF03759; PRONE; 1.
DR   PROSITE; PS51334; PRONE; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..611
FT                   /note="Rop guanine nucleotide exchange factor 5"
FT                   /id="PRO_0000423891"
FT   DOMAIN          93..477
FT                   /note="PRONE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00663"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          588..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   611 AA;  68465 MW;  71FE7A4865ED96FD CRC64;
     MENLVKSCAG IEKKRSNLTP SMEDILTESK ERSSTSGASY ESSSTTTVAS SSPPPPPSQI
     LGWPIRKASF RKNSKESVNF DHKKLTLHDD SGFKAKEMNS ADVEMMKERF AKLLLGEDMS
     GSGKGVCTAL AISNAITNLC ATIFGQLWRL EPLSSEKKEM WRREMEWILS VSDHIVELTP
     STQTYPDGNK FEVMTCRPRF DLFINLPALR KLDNMLLDIL ASFKKTEFWY VDQGIVASEN
     DGSASFRRKI QRQEEKWWLP VPRLAPNGLT EEARTELNHK RECATQILKA AMAINSLALT
     EMDVPKSYLE TLPKNGRSCL GDVIYRYVTS DKFSAESLLD CLDLSSEHIA LDIANRVEAS
     IYVWRRRVQT KLGVNNNTSS TTPKLTWEMV KELMAAGDKR GLLVERSETL LRCLKQRFPS
     LTQTSLDISK IQWNKDIGKS ILESYSRALE SLASNIIARI DDLLYVDDLT KQSDDNNLLS
     SPAVSSIIAH KKVVPLPYLI SASGTPYRTS FSTTPGFSPS MISPKKGERR TPYSSKDTNK
     IIEKGLPSRG YGVRRVLNNY LGMESKLKIC VNPSDNADTA VINQISKDVE EEKKRNSTSV
     HQKGPPKYTV S