ROGFA_ARATH
ID ROGFA_ARATH Reviewed; 493 AA.
AC Q1KS66; A0MFH1;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Rop guanine nucleotide exchange factor 10;
DE Short=AtRopGEF10;
DE AltName: Full=Rho of plants guanine nucleotide exchange factor 10;
GN Name=ROPGEF10; OrderedLocusNames=At5g19560;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY.
RX PubMed=15980860; DOI=10.1038/nature03883;
RA Berken A., Thomas C., Wittinghofer A.;
RT "A new family of RhoGEFs activates the Rop molecular switch in plants.";
RL Nature 436:1176-1180(2005).
CC -!- FUNCTION: Guanine-nucleotide exchange factor (GEF) that acts as an
CC activator of Rop (Rho of plants) GTPases by promoting the exchange of
CC GDP for GTP. {ECO:0000250}.
CC -!- DOMAIN: The PRONE (plant-specific Rop nucleotide exchanger) domain is
CC responsible for the GEF activity. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28705.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF296830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92725.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69740.1; -; Genomic_DNA.
DR EMBL; DQ459196; ABE97194.1; -; mRNA.
DR EMBL; DQ653297; ABK28705.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001318601.1; NM_001343611.1.
DR RefSeq; NP_197457.1; NM_121961.2.
DR AlphaFoldDB; Q1KS66; -.
DR SMR; Q1KS66; -.
DR BioGRID; 17352; 2.
DR DIP; DIP-59397N; -.
DR IntAct; Q1KS66; 2.
DR STRING; 3702.AT5G19560.1; -.
DR PaxDb; Q1KS66; -.
DR PRIDE; Q1KS66; -.
DR EnsemblPlants; AT5G19560.1; AT5G19560.1; AT5G19560.
DR EnsemblPlants; AT5G19560.5; AT5G19560.5; AT5G19560.
DR GeneID; 832076; -.
DR Gramene; AT5G19560.1; AT5G19560.1; AT5G19560.
DR Gramene; AT5G19560.5; AT5G19560.5; AT5G19560.
DR KEGG; ath:AT5G19560; -.
DR Araport; AT5G19560; -.
DR TAIR; locus:2180781; AT5G19560.
DR eggNOG; ENOG502QSGR; Eukaryota.
DR HOGENOM; CLU_019073_1_0_1; -.
DR InParanoid; Q1KS66; -.
DR OMA; SKQMGKN; -.
DR PhylomeDB; Q1KS66; -.
DR PRO; PR:Q1KS66; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q1KS66; baseline and differential.
DR Genevisible; Q1KS66; AT.
DR GO; GO:0016324; C:apical plasma membrane; IDA:TAIR.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:TAIR.
DR InterPro; IPR005512; PRONE_dom.
DR InterPro; IPR038937; RopGEF.
DR PANTHER; PTHR33101; PTHR33101; 1.
DR Pfam; PF03759; PRONE; 1.
DR PROSITE; PS51334; PRONE; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor; Reference proteome.
FT CHAIN 1..493
FT /note="Rop guanine nucleotide exchange factor 10"
FT /id="PRO_0000423895"
FT DOMAIN 35..401
FT /note="PRONE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00663"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 56523 MW; FFE597A6A7BBA6AD CRC64;
MFDGRNSGHS SFSSRGDGMH TPEHELAGHA APSTRRGKQN RRSDMEVMKE RFAKLLLGED
MSGGGTGETS ALALSNAITK LADSMFGEQM KLQPMYPETK ENWRKEMGWL LSVIDHIVQF
VPSRQMGKNG QFTEIMVTKQ RDDLLTNIPA LRKLDSVLLE TLDNFKDQKD FWYVPRDMED
ADHNGDWRRD ENWWLPVVKV PTDGLSEESR RWLQNQKDSV AQVLKAATAI NAHVLSEMHV
PENYIDSLPK NGKTSLGDFL YKSITEESFD PDYFVSFLDL STEHKVLDLK NRIEASMVIW
KRKMCQKEKD GKSQWGSTVS LEKRELFEVR AETILVMLKQ QFPGIPQSSL EVSKIKNNKD
VGQAILESYS RVLESLASKI MSRIEDVLEA DRLVQRQLMG EAETRSESEA ESEYEETEKV
VAAETPNSRK LSDFIGWRLS SDTKKHSSMS DIEFFHKVEQ EKEKPMMKSP RALPKKFSYL
AKLENMRSPS DRH
