ID   ROGFD_ARATH             Reviewed;         576 AA.
AC   F4J1G1; Q9LW73;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Rop guanine nucleotide exchange factor 13 {ECO:0000303|PubMed:15980860};
DE            Short=AtRopGEF13 {ECO:0000303|PubMed:15980860};
DE   AltName: Full=Phytochrome interacting RopGEF 2 {ECO:0000303|PubMed:20551316};
DE   AltName: Full=Rho of plants guanine nucleotide exchange factor 13 {ECO:0000303|PubMed:15980860};
GN   Name=ROPGEF13 {ECO:0000303|PubMed:15980860};
GN   Synonyms=PIRF2 {ECO:0000303|PubMed:20551316};
GN   OrderedLocusNames=At3g16130 {ECO:0000312|Araport:AT3G16130};
GN   ORFNames=MSL1.17 {ECO:0000312|EMBL:BAB02679.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=20551316; DOI=10.1074/jbc.m110.133710;
RA   Shin D.H., Cho M.H., Kim T.L., Yoo J., Kim J.I., Han Y.J., Song P.S.,
RA   Jeon J.S., Bhoo S.H., Hahn T.R.;
RT   "A small GTPase activator protein interacts with cytoplasmic phytochromes
RT   in regulating root development.";
RL   J. Biol. Chem. 285:32151-32159(2010).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=15980860; DOI=10.1038/nature03883;
RA   Berken A., Thomas C., Wittinghofer A.;
RT   "A new family of RhoGEFs activates the Rop molecular switch in plants.";
RL   Nature 436:1176-1180(2005).
RN   [5]
RP   INTERACTION WITH PRK6.
RX   PubMed=26961657; DOI=10.1038/nature17413;
RA   Takeuchi H., Higashiyama T.;
RT   "Tip-localized receptors control pollen tube growth and LURE sensing in
RT   Arabidopsis.";
RL   Nature 531:245-248(2016).
CC   -!- FUNCTION: Guanine-nucleotide exchange factor (GEF) that acts as an
CC       activator of Rop (Rho of plants) GTPases by promoting the exchange of
CC       GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PRK6. {ECO:0000269|PubMed:26961657}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in mature flowers.
CC       {ECO:0000269|PubMed:20551316}.
CC   -!- DOMAIN: The PRONE (plant-specific Rop nucleotide exchanger) domain is
CC       responsible for the GEF activity. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB02679.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB012247; BAB02679.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F4J1G1; -.
DR   SMR; F4J1G1; -.
DR   BioGRID; 6192; 1.
DR   IntAct; F4J1G1; 2.
DR   STRING; 3702.AT3G16130.1; -.
DR   PaxDb; F4J1G1; -.
DR   PRIDE; F4J1G1; -.
DR   Araport; AT3G16130; -.
DR   TAIR; locus:2093467; AT3G16130.
DR   eggNOG; ENOG502QSGR; Eukaryota.
DR   HOGENOM; CLU_019073_1_0_1; -.
DR   InParanoid; F4J1G1; -.
DR   PRO; PR:F4J1G1; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; F4J1G1; baseline and differential.
DR   Genevisible; F4J1G1; AT.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:TAIR.
DR   InterPro; IPR005512; PRONE_dom.
DR   InterPro; IPR038937; RopGEF.
DR   PANTHER; PTHR33101; PTHR33101; 1.
DR   Pfam; PF03759; PRONE; 1.
DR   PROSITE; PS51334; PRONE; 1.
PE   1: Evidence at protein level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..576
FT                   /note="Rop guanine nucleotide exchange factor 13"
FT                   /id="PRO_0000423898"
FT   DOMAIN          119..485
FT                   /note="PRONE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00663"
FT   REGION          557..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   576 AA;  65946 MW;  2F3851AE5A907DE3 CRC64;
     MVKASEKEHE KYKPKLFDLE NVKKKNSSSR HFKRWNSDSA LRIEDPDIDD GTVFKKTATS
     SIQPILPVLA MDEQPQPREA TDEESQKDSG KREIISFLGY NEKFTRDQVI LRFRGLQAKS
     CYFAYVTELE QMKDKFAKLL LGEDMSGGSK GVSSALALSN AITNLAASAF GEIRRLEAIS
     EDKKERWRRE IGWLLSVTDH IVEFSPTHQT NEDGSSMEVM TTKQRTDLVS NIPSLKKLDE
     MLLDCLDKFK DQDEFYYVTP GSPESENSNS TRNDDKWWLP IVKVPPKGLS ETLKRFLLSQ
     RECVCQVLNS AMAINSQVLT EMEIPESYID SLPKKGRASL GDMIYRMITL EMFDAEQFLL
     EMDLSSEHKI LDLKNKFEAS VVIWQRKIVQ IDNKSSSPWS TNLSMDKRQQ LEERAATILQ
     LIKQEFPGIS QSTLDISKIQ FNRDIGLAIV ESYSRILESL AHTVMSRIED VLEADQLTQN
     PELAMCKIHI VKETESPEKE EEPNFCLLED RPKKQKPTIS LSEVMQWNIE TNEPRKEKSD
     KKLLTRVSSM IMSNNKKTTY LESLGTTRSP TAGRYS