AB28B_ARATH
ID AB28B_ARATH Reviewed; 714 AA.
AC Q8LPQ6; O65615; Q67ZJ9; Q67ZN9; Q682F1;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=ABC transporter B family member 28;
DE Short=ABC transporter ABCB.28;
DE Short=AtABCB28;
DE AltName: Full=Non-intrinsic ABC protein 8;
DE AltName: Full=TAP-related protein 1;
GN Name=ABCB28; Synonyms=NAP8; OrderedLocusNames=At4g25450; ORFNames=M7J2.180;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8LPQ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8LPQ6-2; Sequence=VSP_020688;
CC Name=3;
CC IsoId=Q8LPQ6-3; Sequence=VSP_020689;
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA18181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB81355.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL022197; CAA18181.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161563; CAB81355.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85061.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85062.1; -; Genomic_DNA.
DR EMBL; AY094470; AAM19838.1; -; mRNA.
DR EMBL; AK175205; BAD42968.1; -; mRNA.
DR EMBL; AK175416; BAD43179.1; -; mRNA.
DR EMBL; AK175486; BAD43249.1; -; mRNA.
DR EMBL; AK175939; BAD43702.1; -; mRNA.
DR EMBL; AK176078; BAD43841.1; -; mRNA.
DR EMBL; AK176118; BAD43881.1; -; mRNA.
DR EMBL; AK176612; BAD44375.1; -; mRNA.
DR EMBL; AK220751; BAD93929.1; -; mRNA.
DR PIR; T05802; T05802.
DR RefSeq; NP_001031714.1; NM_001036637.2. [Q8LPQ6-3]
DR RefSeq; NP_194275.2; NM_118677.5. [Q8LPQ6-1]
DR AlphaFoldDB; Q8LPQ6; -.
DR SMR; Q8LPQ6; -.
DR STRING; 3702.AT4G25450.1; -.
DR iPTMnet; Q8LPQ6; -.
DR PaxDb; Q8LPQ6; -.
DR PRIDE; Q8LPQ6; -.
DR ProteomicsDB; 244592; -. [Q8LPQ6-1]
DR EnsemblPlants; AT4G25450.1; AT4G25450.1; AT4G25450. [Q8LPQ6-1]
DR EnsemblPlants; AT4G25450.2; AT4G25450.2; AT4G25450. [Q8LPQ6-3]
DR GeneID; 828650; -.
DR Gramene; AT4G25450.1; AT4G25450.1; AT4G25450. [Q8LPQ6-1]
DR Gramene; AT4G25450.2; AT4G25450.2; AT4G25450. [Q8LPQ6-3]
DR KEGG; ath:AT4G25450; -.
DR Araport; AT4G25450; -.
DR TAIR; locus:2131809; AT4G25450.
DR eggNOG; KOG0055; Eukaryota.
DR InParanoid; Q8LPQ6; -.
DR OMA; ERANASC; -.
DR OrthoDB; 684058at2759; -.
DR PhylomeDB; Q8LPQ6; -.
DR PRO; PR:Q8LPQ6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8LPQ6; baseline and differential.
DR Genevisible; Q8LPQ6; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..714
FT /note="ABC transporter B family member 28"
FT /id="PRO_0000250660"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 109..393
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 470..708
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 505..512
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT VAR_SEQ 1..257
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_020688"
FT VAR_SEQ 618..714
FT /note="RVAIARSLLKNAPILILDEATSALDAVSERLVQSALNRLMKDRTTLVIAHRL
FT STVQSANQIAVCSDGKIIELGTHSELVAQKGSYASLVGTQRLAFE -> V (in
FT isoform 3)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_020689"
FT CONFLICT 259
FT /note="L -> P (in Ref. 4; BAD42968/BAD43179/BAD44375)"
FT /evidence="ECO:0000305"
FT CONFLICT 261
FT /note="V -> M (in Ref. 4; BAD43841)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 714 AA; 77926 MW; 5433FECF48AECDCF CRC64;
MASATTLLFH HGSTRVLVAR RRCQASVLRP YGGLKPFLSF CSLPNSTAPF RDSLRAKSDG
LARAYVTGAP PIVEEPDPKI EESKSEAESK DLISWGLLWS LMSKHKLRLS VCLLTLLGCS
TCTLSMPVFS GRFFEVLIGV RPEPLWRLLS KIAVLYSLEP IFTIAFVTNM TAIWENVMAI
LRAQIFRRVL IQKAEFFDKY KVGELTGLLT SDLGALNSIV NDNISRDRGF RAFTEVFGTI
CILFTLSPQL APVLGLLMLA VSVLVAVYKR STVPVYKSHG LAQATMSDCV SETFSAIRTV
RSFSGEKRQM SIFGSQILAY KLSGLKLGTF KSINESITRV AVYISLLALY CLGGSKVKTG
ELAVGTVVSF IGYTFTLTFA VQGLVNTFGD LRGTFAAIDR INSILNAVDI DEALAYGLER
DIHTKKVQDE NLKLFLSAGP NVNIRHLDKY YMSNLKSTNN LRTLTWAGDV CLDDVHFAYP
LRPDVKVLDG LSLTLNSGTV TALVGSSGAG KSTIVQLLAR FYEPTQGRIT VGGEDVRMFD
KSEWAKVVSI VNQEPVLFSL SVAENIAYGL PNEHVSKDDI IKAAKAANAH DFIISLPQGY
DTLVGERGGL LSGGQRQRVA IARSLLKNAP ILILDEATSA LDAVSERLVQ SALNRLMKDR
TTLVIAHRLS TVQSANQIAV CSDGKIIELG THSELVAQKG SYASLVGTQR LAFE
