ID   ROMO1_BOVIN             Reviewed;          79 AA.
AC   Q3SZV8;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Reactive oxygen species modulator 1;
DE            Short=ROS modulator 1;
DE   AltName: Full=Protein MGR2 homolog;
GN   Name=ROMO1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity against a variety of bacteria
CC       including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing
CC       bacterial membrane breakage (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Induces production of reactive oxygen species (ROS) which are
CC       necessary for cell proliferation. May play a role in inducing oxidative
CC       DNA damage and replicative senescence. May play a role in the
CC       coordination of mitochondrial morphology and cell proliferation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MGR2 family. {ECO:0000305}.
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DR   EMBL; BC102685; AAI02686.1; -; mRNA.
DR   RefSeq; NP_001108000.1; NM_001114528.2.
DR   RefSeq; XP_005214932.1; XM_005214875.3.
DR   AlphaFoldDB; Q3SZV8; -.
DR   STRING; 9913.ENSBTAP00000039044; -.
DR   PaxDb; Q3SZV8; -.
DR   PRIDE; Q3SZV8; -.
DR   Ensembl; ENSBTAT00000039245; ENSBTAP00000039044; ENSBTAG00000027361.
DR   GeneID; 618530; -.
DR   KEGG; bta:618530; -.
DR   CTD; 140823; -.
DR   VEuPathDB; HostDB:ENSBTAG00000027361; -.
DR   VGNC; VGNC:34085; ROMO1.
DR   eggNOG; KOG4096; Eukaryota.
DR   GeneTree; ENSGT00390000005315; -.
DR   HOGENOM; CLU_142435_2_0_1; -.
DR   InParanoid; Q3SZV8; -.
DR   OMA; FMIGFCV; -.
DR   OrthoDB; 1635599at2759; -.
DR   TreeFam; TF300273; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000027361; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
DR   GO; GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.
DR   GO; GO:0051838; P:cytolysis by host of symbiont cells; IEA:Ensembl.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0090399; P:replicative senescence; ISS:UniProtKB.
DR   InterPro; IPR018450; Romo1/Mgr2.
DR   PANTHER; PTHR28525; PTHR28525; 1.
DR   Pfam; PF10247; Romo1; 1.
DR   SMART; SM01378; Romo1; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..79
FT                   /note="Reactive oxygen species modulator 1"
FT                   /id="PRO_0000294146"
FT   TRANSMEM        22..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          42..60
FT                   /note="Sufficient for antibacterial activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8183 MW;  AD959C88C89EF80A CRC64;
     MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR ELMGGIGKTM
     MQSGGTFGTF MAIGMGIRC