ROMO1_DANRE
ID ROMO1_DANRE Reviewed; 80 AA.
AC Q6NYD1;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Reactive oxygen species modulator 1;
DE Short=ROS modulator 1;
DE AltName: Full=Protein MGR2 homolog;
GN Name=romo1; ORFNames=zgc:73345;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has antibacterial activity against a variety of bacteria
CC including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing
CC bacterial membrane breakage (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Induces production of reactive oxygen species (ROS) which are
CC necessary for cell proliferation. May play a role in inducing oxidative
CC DNA damage and replicative senescence. May play a role in the
CC coordination of mitochondrial morphology and cell proliferation (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MGR2 family. {ECO:0000305}.
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DR EMBL; BC059661; AAH59661.1; -; mRNA.
DR EMBL; BC066639; AAH66639.1; -; mRNA.
DR RefSeq; NP_957091.1; NM_200797.4.
DR AlphaFoldDB; Q6NYD1; -.
DR STRING; 7955.ENSDARP00000055509; -.
DR PaxDb; Q6NYD1; -.
DR Ensembl; ENSDART00000055510; ENSDARP00000055509; ENSDARG00000038076.
DR GeneID; 393770; -.
DR KEGG; dre:393770; -.
DR CTD; 140823; -.
DR ZFIN; ZDB-GENE-040426-1768; romo1.
DR eggNOG; KOG4096; Eukaryota.
DR GeneTree; ENSGT00390000005315; -.
DR HOGENOM; CLU_142435_2_0_1; -.
DR InParanoid; Q6NYD1; -.
DR OMA; FMIGFCV; -.
DR OrthoDB; 1635599at2759; -.
DR PhylomeDB; Q6NYD1; -.
DR TreeFam; TF300273; -.
DR PRO; PR:Q6NYD1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 6.
DR Bgee; ENSDARG00000038076; Expressed in swim bladder and 33 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR GO; GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0090399; P:replicative senescence; ISS:UniProtKB.
DR InterPro; IPR018450; Romo1/Mgr2.
DR PANTHER; PTHR28525; PTHR28525; 1.
DR Pfam; PF10247; Romo1; 1.
DR SMART; SM01378; Romo1; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..80
FT /note="Reactive oxygen species modulator 1"
FT /id="PRO_0000294147"
FT TRANSMEM 22..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 42..60
FT /note="Sufficient for antibacterial activity"
FT /evidence="ECO:0000250"
SQ SEQUENCE 80 AA; 8381 MW; 520FA4FB2FBAA11E CRC64;
MPVSVGSYGQ QAQPSCFDRV KMGFMMGFAV GMAAGAMFGT FSCLRIGMRG RELMGGVGKT
MMQSGGTFGT FMAIGMGIRC
