ROMO1_MOUSE
ID ROMO1_MOUSE Reviewed; 79 AA.
AC P60603; A2BHV9; Q9CQ98; Q9H1N2;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Reactive oxygen species modulator 1;
DE Short=ROS modulator 1;
DE AltName: Full=Protein MGR2 homolog;
GN Name=Romo1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Liver;
RA Zhao S., Zhang Y., Yu Y., Ge S., Geng Y., Cui C., Yang T.;
RT "Identifying different gene expression using substraction suppresion
RT hybridization.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=16842742; DOI=10.1016/j.bbrc.2006.06.140;
RA Chung Y.M., Kim J.S., Yoo Y.D.;
RT "A novel protein, Romo1, induces ROS production in the mitochondria.";
RL Biochem. Biophys. Res. Commun. 347:649-655(2006).
CC -!- FUNCTION: Has antibacterial activity against a variety of bacteria
CC including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing
CC bacterial membrane breakage (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Induces production of reactive oxygen species (ROS) which are
CC necessary for cell proliferation. May play a role in inducing oxidative
CC DNA damage and replicative senescence. May play a role in the
CC coordination of mitochondrial morphology and cell proliferation (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected in brain, liver and kidney.
CC {ECO:0000269|PubMed:16842742}.
CC -!- SIMILARITY: Belongs to the MGR2 family. {ECO:0000305}.
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DR EMBL; AY028425; AAK18748.1; -; mRNA.
DR EMBL; AK003488; BAB22816.1; -; mRNA.
DR EMBL; AK008300; BAB25585.1; -; mRNA.
DR EMBL; BX649640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028749; AAH28749.1; -; mRNA.
DR CCDS; CCDS38296.1; -.
DR RefSeq; NP_001157688.1; NM_001164216.1.
DR RefSeq; NP_001157689.1; NM_001164217.2.
DR RefSeq; NP_080222.1; NM_025946.6.
DR AlphaFoldDB; P60603; -.
DR STRING; 10090.ENSMUSP00000085981; -.
DR iPTMnet; P60603; -.
DR PhosphoSitePlus; P60603; -.
DR EPD; P60603; -.
DR jPOST; P60603; -.
DR MaxQB; P60603; -.
DR PaxDb; P60603; -.
DR PeptideAtlas; P60603; -.
DR PRIDE; P60603; -.
DR ProteomicsDB; 260828; -.
DR Antibodypedia; 2412; 155 antibodies from 17 providers.
DR DNASU; 67067; -.
DR Ensembl; ENSMUST00000088610; ENSMUSP00000085981; ENSMUSG00000067847.
DR Ensembl; ENSMUST00000109597; ENSMUSP00000105226; ENSMUSG00000067847.
DR Ensembl; ENSMUST00000109598; ENSMUSP00000105227; ENSMUSG00000067847.
DR Ensembl; ENSMUST00000119950; ENSMUSP00000113943; ENSMUSG00000067847.
DR GeneID; 67067; -.
DR KEGG; mmu:67067; -.
DR UCSC; uc008nmm.2; mouse.
DR CTD; 140823; -.
DR MGI; MGI:1914317; Romo1.
DR VEuPathDB; HostDB:ENSMUSG00000067847; -.
DR eggNOG; KOG4096; Eukaryota.
DR GeneTree; ENSGT00390000005315; -.
DR HOGENOM; CLU_142435_2_0_1; -.
DR InParanoid; P60603; -.
DR OMA; FMIGFCV; -.
DR OrthoDB; 1635599at2759; -.
DR PhylomeDB; P60603; -.
DR TreeFam; TF300273; -.
DR BioGRID-ORCS; 67067; 30 hits in 71 CRISPR screens.
DR ChiTaRS; Romo1; mouse.
DR PRO; PR:P60603; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P60603; protein.
DR Bgee; ENSMUSG00000067847; Expressed in epithelium of small intestine and 128 other tissues.
DR Genevisible; P60603; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.
DR GO; GO:0051838; P:cytolysis by host of symbiont cells; ISO:MGI.
DR GO; GO:0042742; P:defense response to bacterium; ISO:MGI.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0090399; P:replicative senescence; ISS:UniProtKB.
DR InterPro; IPR018450; Romo1/Mgr2.
DR PANTHER; PTHR28525; PTHR28525; 1.
DR Pfam; PF10247; Romo1; 1.
DR SMART; SM01378; Romo1; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..79
FT /note="Reactive oxygen species modulator 1"
FT /id="PRO_0000079434"
FT TRANSMEM 22..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 42..60
FT /note="Sufficient for antibacterial activity"
FT /evidence="ECO:0000250"
SQ SEQUENCE 79 AA; 8183 MW; AD959C88C89EF80A CRC64;
MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR ELMGGIGKTM
MQSGGTFGTF MAIGMGIRC
