ID   ROMO1_PIG               Reviewed;          79 AA.
AC   A1XQR6;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Reactive oxygen species modulator 1;
DE            Short=ROS modulator 1;
DE   AltName: Full=Protein MGR2 homolog;
GN   Name=ROMO1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Longissimus dorsi muscle;
RA   Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.;
RT   "Generation and analysis of cDNA sequences derived from a porcine skeletal
RT   muscle library.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity against a variety of bacteria
CC       including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing
CC       bacterial membrane breakage (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Induces production of reactive oxygen species (ROS) which are
CC       necessary for cell proliferation. May play a role in inducing oxidative
CC       DNA damage and replicative senescence. May play a role in the
CC       coordination of mitochondrial morphology and cell proliferation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MGR2 family. {ECO:0000305}.
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DR   EMBL; DQ629137; ABK55622.1; -; mRNA.
DR   AlphaFoldDB; A1XQR6; -.
DR   STRING; 9823.ENSSSCP00000007782; -.
DR   PaxDb; A1XQR6; -.
DR   PeptideAtlas; A1XQR6; -.
DR   eggNOG; KOG4096; Eukaryota.
DR   InParanoid; A1XQR6; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0090399; P:replicative senescence; ISS:UniProtKB.
DR   InterPro; IPR018450; Romo1/Mgr2.
DR   PANTHER; PTHR28525; PTHR28525; 1.
DR   Pfam; PF10247; Romo1; 1.
DR   SMART; SM01378; Romo1; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..79
FT                   /note="Reactive oxygen species modulator 1"
FT                   /id="PRO_0000289657"
FT   TRANSMEM        22..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          42..60
FT                   /note="Sufficient for antibacterial activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8175 MW;  A8D08DC8C89EF80A CRC64;
     MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGPF SCLRIGMRGR ELMGGIGKTM
     MQSGGTFGPF MAIGMGIRC