ID   ROMO1_XENLA             Reviewed;          79 AA.
AC   Q4V7T9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Reactive oxygen species modulator 1;
DE            Short=ROS modulator 1;
DE   AltName: Full=Protein MGR2 homolog;
GN   Name=romo1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity against a variety of bacteria
CC       including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing
CC       bacterial membrane breakage (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Induces production of reactive oxygen species (ROS) which are
CC       necessary for cell proliferation. May play a role in inducing oxidative
CC       DNA damage and replicative senescence. May play a role in the
CC       coordination of mitochondrial morphology and cell proliferation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MGR2 family. {ECO:0000305}.
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DR   EMBL; BC097721; AAH97721.1; -; mRNA.
DR   RefSeq; NP_001165118.1; NM_001171647.1.
DR   RefSeq; XP_018090079.1; XM_018234590.1.
DR   RefSeq; XP_018090080.1; XM_018234591.1.
DR   RefSeq; XP_018093913.1; XM_018238424.1.
DR   RefSeq; XP_018093914.1; XM_018238425.1.
DR   AlphaFoldDB; Q4V7T9; -.
DR   DNASU; 734542; -.
DR   GeneID; 108702766; -.
DR   GeneID; 734542; -.
DR   KEGG; xla:108702766; -.
DR   KEGG; xla:734542; -.
DR   CTD; 734542; -.
DR   Xenbase; XB-GENE-982445; romo1.L.
DR   OrthoDB; 1635599at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 108702766; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
DR   GO; GO:0090399; P:replicative senescence; ISS:UniProtKB.
DR   InterPro; IPR018450; Romo1/Mgr2.
DR   PANTHER; PTHR28525; PTHR28525; 1.
DR   Pfam; PF10247; Romo1; 1.
DR   SMART; SM01378; Romo1; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..79
FT                   /note="Reactive oxygen species modulator 1"
FT                   /id="PRO_0000294148"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          42..60
FT                   /note="Sufficient for antibacterial activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8306 MW;  126B6F6A4F32BED1 CRC64;
     MPVAVGPYGQ SQPNCFDRVK MGFMMGFAVG MAAGALFGTF SCLRFGMRGR ELMGGVGKTM
     MQSGGTFGTF MAIGMGIRC