ROMO1_XENTR
ID ROMO1_XENTR Reviewed; 79 AA.
AC A4QNF3;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Reactive oxygen species modulator 1;
DE Short=ROS modulator 1;
DE AltName: Full=Protein MGR2 homolog;
GN Name=romo1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has antibacterial activity against a variety of bacteria
CC including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing
CC bacterial membrane breakage (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Induces production of reactive oxygen species (ROS) which are
CC necessary for cell proliferation. May play a role in inducing oxidative
CC DNA damage and replicative senescence. May play a role in the
CC coordination of mitochondrial morphology and cell proliferation (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MGR2 family. {ECO:0000305}.
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DR EMBL; BC135588; AAI35589.1; -; mRNA.
DR RefSeq; NP_001165117.1; NM_001171646.1.
DR RefSeq; XP_017953153.1; XM_018097664.1.
DR AlphaFoldDB; A4QNF3; -.
DR PaxDb; A4QNF3; -.
DR DNASU; 100125151; -.
DR Ensembl; ENSXETT00000054288; ENSXETP00000054288; ENSXETG00000025474.
DR GeneID; 100125151; -.
DR KEGG; xtr:100125151; -.
DR CTD; 140823; -.
DR Xenbase; XB-GENE-982441; romo1.
DR eggNOG; KOG4096; Eukaryota.
DR HOGENOM; CLU_142435_2_0_1; -.
DR InParanoid; A4QNF3; -.
DR OMA; RPMILPR; -.
DR OrthoDB; 1635599at2759; -.
DR PhylomeDB; A4QNF3; -.
DR TreeFam; TF300273; -.
DR Proteomes; UP000008143; Chromosome 10.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000025474; Expressed in brain and 12 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR GO; GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0090399; P:replicative senescence; ISS:UniProtKB.
DR InterPro; IPR018450; Romo1/Mgr2.
DR PANTHER; PTHR28525; PTHR28525; 1.
DR Pfam; PF10247; Romo1; 1.
DR SMART; SM01378; Romo1; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..79
FT /note="Reactive oxygen species modulator 1"
FT /id="PRO_0000294149"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 42..60
FT /note="Sufficient for antibacterial activity"
FT /evidence="ECO:0000250"
SQ SEQUENCE 79 AA; 8279 MW; 127A8E9A5ED34ED1 CRC64;
MPVAVGPYGQ SQPSCFDRVK MGFMMGFAVG MAAGALFGTF SCLRFGMRGR ELMGGVGKTM
MQSGGTFGTF MAIGMGIRC
