ID   ROP1L_BOVIN             Reviewed;         218 AA.
AC   Q3T024;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Ropporin-1-like protein;
GN   Name=ROPN1L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important for male fertility. With ROPN1, involved in fibrous
CC       sheath integrity and sperm motility, plays a role in PKA-dependent
CC       signaling processes required for spermatozoa capacitation.
CC       {ECO:0000250|UniProtKB:Q9EQ00}.
CC   -!- SUBUNIT: May interact with AKAP3 (By similarity). Interacts with FSCB;
CC       the interaction increases upon spermatozoa capacitation conditions (By
CC       similarity). {ECO:0000250|UniProtKB:Q96C74,
CC       ECO:0000250|UniProtKB:Q9EQ00}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q9EQ00}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96C74}.
CC   -!- PTM: Sumoylated, sumoylation decreases upon spermatozoa capacitation
CC       conditions. {ECO:0000250|UniProtKB:Q9EQ00}.
CC   -!- SIMILARITY: Belongs to the ropporin family. {ECO:0000305}.
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DR   EMBL; BC102601; AAI02602.1; -; mRNA.
DR   RefSeq; NP_001069185.1; NM_001075717.2.
DR   AlphaFoldDB; Q3T024; -.
DR   IntAct; Q3T024; 1.
DR   MINT; Q3T024; -.
DR   STRING; 9913.ENSBTAP00000036517; -.
DR   PaxDb; Q3T024; -.
DR   GeneID; 515565; -.
DR   KEGG; bta:515565; -.
DR   CTD; 83853; -.
DR   eggNOG; ENOG502QTNR; Eukaryota.
DR   InParanoid; Q3T024; -.
DR   OrthoDB; 1316863at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0048240; P:sperm capacitation; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Flagellum; Reference proteome; Ubl conjugation.
FT   CHAIN           1..218
FT                   /note="Ropporin-1-like protein"
FT                   /id="PRO_0000307397"
FT   DOMAIN          17..46
FT                   /note="RIIa"
SQ   SEQUENCE   218 AA;  24426 MW;  674077CFD95FE444 CRC64;
     MPLPDTMFCA QQIHIPPELT DILKQFTKAA IRTQPADVLQ WSAGYFSALS RGDPLPVKDR
     IEMPMATQKT DTGLTQGLLK VLHKQCSHKE YVDLADLEQK WKNLCLPVEK FRALLQLDPC
     EDKIEWIKFL ALGCSMLGGS LNTAMKHLCE ILTTDPEGGP ARIPFGTFSY VYRYLSGLDS
     DIPESDTEAY LSSLKENAAA RKNGMIGLSD FFVLKRKI