ID   ROP1L_DANRE             Reviewed;         218 AA.
AC   Q66IC9; Q7T169;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Ropporin-1-like protein;
GN   Name=ropn1l; ORFNames=si:rp71-1f1.7;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important for male fertility. With ROPN1, involved in fibrous
CC       sheath integrity and sperm motility, plays a role in PKA-dependent
CC       signaling processes required for spermatozoa capacitation.
CC       {ECO:0000250|UniProtKB:Q9EQ00}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q9EQ00}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96C74}.
CC   -!- SIMILARITY: Belongs to the ropporin family. {ECO:0000305}.
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DR   EMBL; AL627129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC081402; AAH81402.1; -; mRNA.
DR   EMBL; BC152162; AAI52163.1; -; mRNA.
DR   RefSeq; NP_001004624.1; NM_001004624.1.
DR   AlphaFoldDB; Q66IC9; -.
DR   STRING; 7955.ENSDARP00000075677; -.
DR   PaxDb; Q66IC9; -.
DR   Ensembl; ENSDART00000081234; ENSDARP00000075677; ENSDARG00000058370.
DR   Ensembl; ENSDART00000188597; ENSDARP00000154104; ENSDARG00000114122.
DR   GeneID; 798354; -.
DR   KEGG; dre:798354; -.
DR   CTD; 83853; -.
DR   ZFIN; ZDB-GENE-040724-235; ropn1l.
DR   eggNOG; ENOG502QTNR; Eukaryota.
DR   GeneTree; ENSGT00390000012731; -.
DR   HOGENOM; CLU_069829_1_0_1; -.
DR   InParanoid; Q66IC9; -.
DR   OMA; DSRKNGM; -.
DR   OrthoDB; 1316863at2759; -.
DR   PhylomeDB; Q66IC9; -.
DR   TreeFam; TF105421; -.
DR   PRO; PR:Q66IC9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 24.
DR   Bgee; ENSDARG00000058370; Expressed in testis and 15 other tissues.
DR   ExpressionAtlas; Q66IC9; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0048240; P:sperm capacitation; IBA:GO_Central.
DR   GO; GO:0007286; P:spermatid development; IMP:ZFIN.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Flagellum; Reference proteome.
FT   CHAIN           1..218
FT                   /note="Ropporin-1-like protein"
FT                   /id="PRO_0000307401"
FT   DOMAIN          17..54
FT                   /note="RIIa"
FT   REGION          199..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   218 AA;  24171 MW;  3242C32C57E01903 CRC64;
     MPLSETMYCA QQINIPPALP NMLKQFTKAA IRTQPRDVLQ WAADYFSALS KGQDLPVKKR
     LELPVATQKT DTGLTPGLLK ILHQQLTSKE TVTKDELLPK WKALHLPVEQ LDTILALGNF
     SENINWMQFF ALACSALGGS ITSALKHACE ILTEDPEGGP AQIPFHMFRS LYTYLAHLDG
     EIPEEQIDSF LHSLEGQAQS QGGMVQPSNF TSLHTAEK