ID   ROP1L_MACFA             Reviewed;         230 AA.
AC   Q4R760;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Ropporin-1-like protein;
GN   Name=ROPN1L; ORFNames=QtsA-16243;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important for male fertility. With ROPN1, involved in fibrous
CC       sheath integrity and sperm motility, plays a role in PKA-dependent
CC       signaling processes required for spermatozoa capacitation.
CC       {ECO:0000250|UniProtKB:Q9EQ00}.
CC   -!- SUBUNIT: May interact with AKAP3 (By similarity). Interacts with FSCB;
CC       the interaction increases upon spermatozoa capacitation conditions (By
CC       similarity). {ECO:0000250|UniProtKB:Q96C74,
CC       ECO:0000250|UniProtKB:Q9EQ00}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q9EQ00}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96C74}.
CC   -!- PTM: Sumoylated, sumoylation decreases upon spermatozoa capacitation
CC       conditions. {ECO:0000250|UniProtKB:Q9EQ00}.
CC   -!- SIMILARITY: Belongs to the ropporin family. {ECO:0000305}.
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DR   EMBL; AB168965; BAE01063.1; -; mRNA.
DR   RefSeq; NP_001271606.1; NM_001284677.1.
DR   AlphaFoldDB; Q4R760; -.
DR   STRING; 9541.XP_005556651.1; -.
DR   GeneID; 101865380; -.
DR   CTD; 83853; -.
DR   eggNOG; ENOG502QTNR; Eukaryota.
DR   OrthoDB; 1316863at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0048240; P:sperm capacitation; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Flagellum; Reference proteome; Ubl conjugation.
FT   CHAIN           1..230
FT                   /note="Ropporin-1-like protein"
FT                   /id="PRO_0000307399"
FT   DOMAIN          17..54
FT                   /note="RIIa"
SQ   SEQUENCE   230 AA;  26084 MW;  DBFEBEF2F4F4B665 CRC64;
     MPLPDTMFCA QQIHIPPELP DILKQFTKAA IRTQPADVLQ WSAGYFSALS RGDPLPVKDR
     MEMPTATQKT DTGLTPGLLK VLHKQCHHKQ YVELTDLEQK WKNLCLPKEK FKALLQLDPC
     ENRIKWINFL ALGCSMLGGS LNTALKHLCE ILTDDPEGGP ARIPFKTFSY VYRYLANLDS
     DVSSSETESY LASLKENIDT RRNGMIGLSD FFFPKRNLLE NRENSEDVGH