ID   ROP1_BOVIN              Reviewed;         212 AA.
AC   Q3T064;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Ropporin-1;
DE   AltName: Full=Rhophilin-associated protein 1;
GN   Name=ROPN1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important for male fertility. With ROPN1L, involved in
CC       fibrous sheath integrity and sperm motility, plays a role in PKA-
CC       dependent signaling processes required for spermatozoa capacitation.
CC       {ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- SUBUNIT: Homodimer. Interacts with AKAP3 (By similarity). May interact
CC       with SPA17 (By similarity). Interacts with RHPN1 (By similarity).
CC       Interacts with FSCB; the interaction increases upon spermatozoa
CC       capacitation conditions (By similarity). {ECO:0000250|UniProtKB:Q96C74,
CC       ECO:0000250|UniProtKB:Q9BZX4, ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q9ESG2}. Note=In the sperm tail, found in the
CC       principal piece and in the cytoplasmic droplet located at the distal
CC       end of the midpiece. Inner surface of the fibrous sheath.
CC       {ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- DOMAIN: The RIIa domain mediates interaction with AKAP3. {ECO:0000250}.
CC   -!- PTM: Sumoylated, sumoylation decreases upon spermatozoa capacitation
CC       conditions. {ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- MISCELLANEOUS: 'Ropporin' comes from the Japanese word 'oppo' which
CC       means 'tail'.
CC   -!- SIMILARITY: Belongs to the ropporin family. {ECO:0000305}.
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DR   EMBL; BC102549; AAI02550.1; -; mRNA.
DR   RefSeq; NP_001069368.1; NM_001075900.1.
DR   AlphaFoldDB; Q3T064; -.
DR   IntAct; Q3T064; 1.
DR   MINT; Q3T064; -.
DR   STRING; 9913.ENSBTAP00000009113; -.
DR   PaxDb; Q3T064; -.
DR   GeneID; 527583; -.
DR   KEGG; bta:527583; -.
DR   CTD; 54763; -.
DR   eggNOG; ENOG502R2JI; Eukaryota.
DR   InParanoid; Q3T064; -.
DR   OrthoDB; 1316863at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0048240; P:sperm capacitation; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Flagellum; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..212
FT                   /note="Ropporin-1"
FT                   /id="PRO_0000307391"
FT   DOMAIN          12..43
FT                   /note="RIIa"
FT   REGION          209..212
FT                   /note="Interaction with RHPN1"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4KLL5"
SQ   SEQUENCE   212 AA;  23969 MW;  6128EB2DCE54B0EC CRC64;
     MPQTDKQICI PPELPELLKQ FTKAAIRSQP QDLIQWAAEY FGAMSRGEIP PVRERSERVA
     LSNWAELTPE LLKILHSRVG GRLIVQADEL AQMWKVLNLP TDLFNSVMNV GRFTEEIEWL
     KFLALACSSL GVTIAKTLKI VCEVLSSDHD SGPPRIPFST FQFLYTYIAE VDGEISASHV
     SRMLNYIEQE VIGPDGLIKV NDFTQNPRVR LE