ID   ROP1_MACFA              Reviewed;         212 AA.
AC   Q4R6C5; Q9BE25;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Ropporin-1;
DE   AltName: Full=Rhophilin-associated protein 1;
GN   Name=ROPN1; ORFNames=QflA-14788, QtsA-18306;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Frontal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important for male fertility. With ROPN1L, involved in
CC       fibrous sheath integrity and sperm motility, plays a role in PKA-
CC       dependent signaling processes required for spermatozoa capacitation.
CC       {ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- SUBUNIT: Homodimer. Interacts with AKAP3 (By similarity). May interact
CC       with SPA17 (By similarity). Interacts with RHPN1 (By similarity).
CC       Interacts with FSCB; the interaction increases upon spermatozoa
CC       capacitation conditions (By similarity). {ECO:0000250|UniProtKB:Q96C74,
CC       ECO:0000250|UniProtKB:Q9BZX4, ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q9ESG2}. Note=In the sperm tail, found in the
CC       principal piece and in the cytoplasmic droplet located at the distal
CC       end of the midpiece. Inner surface of the fibrous sheath.
CC       {ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q4R6C5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q4R6C5-2; Sequence=VSP_028746;
CC   -!- DOMAIN: The RIIa domain mediates interaction with AKAP3. {ECO:0000250}.
CC   -!- PTM: Sumoylated, sumoylation decreases upon spermatozoa capacitation
CC       conditions. {ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- MISCELLANEOUS: 'Ropporin' comes from the Japanese word 'oppo' which
CC       means 'tail'.
CC   -!- SIMILARITY: Belongs to the ropporin family. {ECO:0000305}.
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DR   EMBL; AB060221; BAB41155.1; -; mRNA.
DR   EMBL; AB169260; BAE01350.1; -; mRNA.
DR   RefSeq; NP_001270153.1; NM_001283224.1. [Q4R6C5-1]
DR   AlphaFoldDB; Q4R6C5; -.
DR   STRING; 9541.XP_005548002.1; -.
DR   Ensembl; ENSMFAT00000029276; ENSMFAP00000001101; ENSMFAG00000040261. [Q4R6C5-1]
DR   GeneID; 101866006; -.
DR   CTD; 152015; -.
DR   eggNOG; ENOG502R2JI; Eukaryota.
DR   GeneTree; ENSGT00390000012731; -.
DR   Proteomes; UP000233100; Chromosome 2.
DR   Bgee; ENSMFAG00000040261; Expressed in skeletal muscle tissue.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0048240; P:sperm capacitation; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cilium; Flagellum; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..212
FT                   /note="Ropporin-1"
FT                   /id="PRO_0000307394"
FT   DOMAIN          12..49
FT                   /note="RIIa"
FT   REGION          209..212
FT                   /note="Interaction with RHPN1"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4KLL5"
FT   VAR_SEQ         1..92
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028746"
SQ   SEQUENCE   212 AA;  23843 MW;  FC6AD47F08DD9C81 CRC64;
     MAQTDKPTCI PPELPKMLKE FAKAAIRAQP QDLIQWGADY FEALSRGETP PVREQSERVA
     LCNWAELTPE VLKILHSQVA GRLIVHAEEL AQMWKVVNLP ADLFNSVMNV GRFTEEIEWL
     KFLALACSAL GVTITKTLKI VCEVLSCDHN GGLPRIPFST FQFLYTYIAE VDGEISASHV
     SRMLNYIEQE VIGPDGLITV NDFTQNPRVW LE