ID   ROP1_MESAU              Reviewed;         129 AA.
AC   P86196;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Ropporin-1 {ECO:0000250|UniProtKB:Q9ESG2};
DE   AltName: Full=Rhophilin-associated protein 1 {ECO:0000250|UniProtKB:Q9ESG2};
DE   Flags: Fragments;
GN   Name=ROPN1 {ECO:0000250|UniProtKB:Q9ESG2};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=20400973; DOI=10.1038/aja.2010.19;
RA   Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.;
RT   "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen
RT   (GP96) are unique to hamster caput epididymal spermatozoa.";
RL   Asian J. Androl. 12:344-355(2010).
CC   -!- FUNCTION: Important for male fertility. With ROPN1L, involved in
CC       fibrous sheath integrity and sperm motility, plays a role in PKA-
CC       dependent signaling processes required for spermatozoa capacitation.
CC       {ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- SUBUNIT: Homodimer. Interacts with AKAP3 (By similarity). May interact
CC       with SPA17 (By similarity). Interacts with RHPN1 (By similarity).
CC       Interacts with FSCB; the interaction increases upon spermatozoa
CC       capacitation conditions (By similarity). {ECO:0000250|UniProtKB:Q96C74,
CC       ECO:0000250|UniProtKB:Q9BZX4, ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q9ESG2}. Note=In the sperm tail, found in the
CC       principal piece and in the cytoplasmic droplet located at the distal
CC       end of the midpiece. Inner surface of the fibrous sheath.
CC       {ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- DOMAIN: The RIIa domain mediates interaction with AKAP3.
CC       {ECO:0000250|UniProtKB:Q9BZX4}.
CC   -!- PTM: Sumoylated, sumoylation decreases upon spermatozoa capacitation
CC       conditions. {ECO:0000250|UniProtKB:Q9ESG2}.
CC   -!- MISCELLANEOUS: 'Ropporin' comes from the Japanese word 'oppo' which
CC       means 'tail'.
CC   -!- SIMILARITY: Belongs to the ropporin family. {ECO:0000255}.
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DR   AlphaFoldDB; P86196; -.
DR   PRIDE; P86196; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0048240; P:sperm capacitation; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Flagellum; Reference proteome; Ubl conjugation.
FT   CHAIN           1..>129
FT                   /note="Ropporin-1"
FT                   /id="PRO_0000394403"
FT   DOMAIN          11..34
FT                   /note="RIIa"
FT                   /evidence="ECO:0000255"
FT   NON_CONS        18..19
FT                   /evidence="ECO:0000305"
FT   NON_CONS        44..45
FT                   /evidence="ECO:0000305"
FT   NON_CONS        57..58
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         129
SQ   SEQUENCE   129 AA;  14595 MW;  BE2C968B2DA2467D CRC64;
     PQTDKQVCIP PELPELLKTQ PPDLIQWAAE YFGAMSRGEI PPVRLIIHAD ELAQMWKTLK
     IVCEVLSCDH DGGPPRIPFS TFQFLYTYIA EVDGEISSSH VSRMLNYIEQ EVIGPDGLIK
     VNDFTQNPR