ROPE_PLACH
ID ROPE_PLACH Reviewed; 1939 AA.
AC Q25662;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Repetitive organellar protein {ECO:0000303|PubMed:9747969};
GN Name=ROPE {ECO:0000303|PubMed:9747969};
OS Plasmodium chabaudi.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=5825 {ECO:0000312|EMBL:AAC63403.1};
RN [1] {ECO:0000312|EMBL:AAC63403.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=96V {ECO:0000312|EMBL:AAC63403.1};
RA Werner E.B., Holder A.A., Aszodi A., Taylor W.R.;
RT "A novel 11-residue coiled-coil motif predicts a histidine zipper.";
RL Protein Pept. Lett. 3:139-146(1996).
RN [2] {ECO:0000312|EMBL:AAC63403.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND DOMAIN.
RC STRAIN=96V {ECO:0000312|EMBL:AAC63403.1};
RX PubMed=9747969; DOI=10.1016/s0166-6851(98)00067-x;
RA Werner E.B., Taylor W.R., Holder A.A.;
RT "A Plasmodium chabaudi protein contains a repetitive region with a
RT predicted spectrin-like structure.";
RL Mol. Biochem. Parasitol. 94:185-196(1998).
CC -!- SUBCELLULAR LOCATION: Host cell membrane
CC {ECO:0000250|UniProtKB:O96133}. Note=Localizes to a punctate structure
CC in the cytoplasm which could correspond the rhoptry or another apical
CC organelle (PubMed:9747969). Localizes to the cell surface of the host
CC erythrocytes (By similarity). {ECO:0000250|UniProtKB:O96133,
CC ECO:0000269|PubMed:9747969}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the asexual blood stage including
CC in schizonts and free merozoites (at protein level).
CC {ECO:0000269|PubMed:9747969}.
CC -!- DOMAIN: The leucine-histidine zipper domain contains 32 11-mer repeats
CC divided by two 6-mer repeats into three blocks.
CC {ECO:0000269|PubMed:9747969}.
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DR EMBL; U43145; AAC63403.1; -; Genomic_DNA.
DR PIR; T18372; T18372.
DR SMR; Q25662; -.
DR VEuPathDB; PlasmoDB:PCHAS_0303200; -.
DR HOGENOM; CLU_243476_0_0_1; -.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Coiled coil; Host cell membrane; Host membrane; Membrane; Repeat;
KW TPR repeat.
FT CHAIN 1..1939
FT /note="Repetitive organellar protein"
FT /id="PRO_0000453699"
FT REPEAT 1089..1122
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 1466..1499
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..1076
FT /note="Leucine-Histidine zipper"
FT /evidence="ECO:0000305|PubMed:9747969"
FT REGION 1520..1547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 88..644
FT /evidence="ECO:0000255"
FT COILED 1041..1161
FT /evidence="ECO:0000255"
FT COILED 1249..1410
FT /evidence="ECO:0000255"
FT COILED 1472..1520
FT /evidence="ECO:0000255"
SQ SEQUENCE 1939 AA; 229003 MW; B36E462001C6F22F CRC64;
MIFNLKKSKK NEDGSNKDSK KTNETSGIEK KEKSNKWYNK IVNNSTKKDK DKNNDSIVYD
DESKVGENDH HMKEYELEDQ LKETLKSITA LSIKVKEYEV KIEELEKELK LEKEKQINKE
YEKELNEKSE FIKRQMELLK EKELNINLKE NKINNKEIIT LKREEKLNDI ESEYIEKNKE
KEKLNYEVTN IKMSLDKLTC EVQEKKDNLE KINKKVIEKE NNLRELKEFM KEKNEIIESL
DGTINDKKNA YEKLEISFEE KRKMIEMLDS KLIEKEENFA NKQAKLEKEN EIIIEKLKDI
ESREKDFKSK EEKFASMENE LNTLKSDLSK NACQMEVYKL EIKDLSQSLV EKEREIFEIK
NEYDDKINNM KEKLSSINDK GIDNTVLHSE EEKINKLLKE KETELNEIHK KYNLEIETIK
NELNEKEEEL EKNKKAHTVE VTNLTKEIKL LEKKTEDAKE GHKNELNELN NQLSKLNKEK
DNIKNENTEL NDKISSLNSE VNILNKDKQT LGNDIKTLND LINNLKNEIN TSDNKMNKMK
EDLAMLNEEM EGKCVVIDEI EKKYKNEIFM LEEKLKEKEN YADLNDEISI LRNSIYVKEK
EFIEMKEFYE NKINLFNKNF EEKKNIYENE LNSLRLKYDN EQGLIKQIDE LNIQKLKTEE
KYLQLYNDNM HMFRSICTKI DMPYSENIKG SDLVDFVTAY IKRRDESSSD ANPDTTHKEM
VAELEKRHAA IVAELEEKHK EEIAKLGEGH KEVVLRLGEQ HKEETIILEE KHKDVVTKLG
EQHKENIIKL EEEHKDVVTK LGDQYKEEIA KLKEEHAVVV AELEEKHKLG EGHKEMVDEL
EKRHADFVEG LEEKHKAETA KLEEGHKSEM NEVEKRHADF VEGLEEKHKA ETAKLGEGHR
EVVAGLEEKH KEVVAELEEK HKEEIAKLEE GHKEVMAELG EKHKEVVAGL EAKHNLEEGH
KEMVAELEKR HADLVAVLEE QHKAEIIKLG EEHKEVVAGI EEKYKVEAIK LAEEHKDVVT
KLGEQHKEEI AKLEDGHKEV VNEVEKKNAS LLNMLEENHK NEMIKLKEEH KESASDLVEK
LYQKDEEVKN SNNKIEELTN VIKDLNDSIM CYKKQILEEV EKRNEYNEEI NKLKIVQNEM
KDMNDKKILE KENEIKKLNK KLSNYKVFET KENTYKNSEM VVNENKERII VDSVCKENIS
ESDVEGKGGN LKMTLSLKKK ERNIFSINDN KNESSELVDT IKSAYINKIE MYKKEIEDNG
KNIEDLKNKI LDLSNELINL ENMKNVLTDE NNNLKKEIEI KDNKLNEKEK NENTEILNLN
DDIIKLKKEI SEWKDEEEKL TKENIKLKND IEQINKEYKI KEENLMIKFN ENINEVTSLK
NQIEIEKMKL EELNKNYELL LAEKRETNMS ISNDDNKIVE NNILEDTDSK QNNLNKNVED
KTGDDINCEK NNDQAKEISY LKDEIKKISM LYGEELNRKN SYDEKVKNLT NELKELKIRN
KKGEEAIAEL NKLKNIKEKN KSVKQNDESS SNNIITKDGD KTPEYVSNDD KIQKDWKANL
VLKLKEKPDL WDNINSLEKE NFRVMSIVKE NKNVQNDKIV GIYSYFKKCE KELKNDMLVI
CLVLKDILSI LFLNDNFVNL FEKIDKILWK QMYIPTEIRI LFLRYFSFLD KLRNYVKCVN
EEYVNNERYE YSWALFQTYL ETASNLKKEM IYYVLEKAEK DSCENNSSNF DKPKITDILN
FSKDSIRLKT IAQLRKELNF EREAKNILNY DYQIILNKYH ECLRKLKIVK NMARELDFNY
NVSSKFSIKK ELEMCSDEND EFKYNNIKNN EEKNDTIKDP KHNNLIQKII NLQRNKKTEK
KKNNLVNEIN TMYPGDTTPK GKIFTTNDNS KQNEILKKKD NINNNITHKN VYTGQVKNIF
NEPVERKVRI SFIHKSPFN
