ROP_DROME
ID ROP_DROME Reviewed; 597 AA.
AC Q07327; Q24010; Q9VZH8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Protein ROP;
GN Name=Rop; Synonyms=cs1; ORFNames=CG15811;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8404533; DOI=10.1242/dev.117.4.1309;
RA Salzberg A., Cohen N., Halachmi N., Kimchie Z., Lev Z.;
RT "The Drosophila Ras2 and Rop gene pair: a dual homology with a yeast Ras-
RT like gene and a suppressor of its loss-of-function phenotype.";
RL Development 117:1309-1319(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Iso-1 / Kennison;
RX PubMed=7917291; DOI=10.1016/0896-6273(94)90025-6;
RA Harrison S.D., Broadie K., de Goor J., Rubin G.M.;
RT "Mutations in the Drosophila Rop gene suggest a function in general
RT secretion and synaptic transmission.";
RL Neuron 13:555-566(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: May be a component of one of the vesicle trafficking
CC pathways. May interact functionally with Ras2 protein.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305}. Membrane
CC {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Soluble
CC or bound to membranes. {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expression is low in unfertilized eggs and early
CC embryos, increases in older embryos and young larvae, is low in mature
CC larvae and increases strongly in pupae and adult flies. Expression
CC during embryogenesis is restricted to the central nervous system (CNS)
CC and the Garland cells, a small group of nephrocytes that takes up waste
CC materials from the hemolymph by endocytosis. In post embryonic stages,
CC expression is seen in the larval salivary glands and the CNS, and in
CC the adult CNS and reproductive systems.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR EMBL; X67218; CAA47658.1; -; mRNA.
DR EMBL; X67219; CAA47659.1; -; mRNA.
DR EMBL; U15967; AAB60242.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF47844.1; -; Genomic_DNA.
DR EMBL; AY052094; AAK93518.1; -; mRNA.
DR PIR; S33578; S33578.
DR RefSeq; NP_001261404.1; NM_001274475.1.
DR RefSeq; NP_523916.2; NM_079192.3.
DR AlphaFoldDB; Q07327; -.
DR SMR; Q07327; -.
DR BioGRID; 63973; 26.
DR DIP; DIP-18152N; -.
DR IntAct; Q07327; 1.
DR STRING; 7227.FBpp0302752; -.
DR PaxDb; Q07327; -.
DR PRIDE; Q07327; -.
DR DNASU; 38493; -.
DR EnsemblMetazoa; FBtr0073263; FBpp0073119; FBgn0004574.
DR EnsemblMetazoa; FBtr0310632; FBpp0302752; FBgn0004574.
DR GeneID; 38493; -.
DR KEGG; dme:Dmel_CG15811; -.
DR CTD; 38493; -.
DR FlyBase; FBgn0004574; Rop.
DR VEuPathDB; VectorBase:FBgn0004574; -.
DR eggNOG; KOG1300; Eukaryota.
DR GeneTree; ENSGT00940000155127; -.
DR HOGENOM; CLU_009210_2_1_1; -.
DR InParanoid; Q07327; -.
DR OMA; RNQYKCA; -.
DR OrthoDB; 725424at2759; -.
DR PhylomeDB; Q07327; -.
DR Reactome; R-DME-114516; Disinhibition of SNARE formation.
DR Reactome; R-DME-114608; Platelet degranulation.
DR Reactome; R-DME-181429; Serotonin Neurotransmitter Release Cycle.
DR Reactome; R-DME-181430; Norepinephrine Neurotransmitter Release Cycle.
DR Reactome; R-DME-210500; Glutamate Neurotransmitter Release Cycle.
DR Reactome; R-DME-212676; Dopamine Neurotransmitter Release Cycle.
DR Reactome; R-DME-264642; Acetylcholine Neurotransmitter Release Cycle.
DR Reactome; R-DME-449836; Other interleukin signaling.
DR Reactome; R-DME-888590; GABA synthesis, release, reuptake and degradation.
DR SignaLink; Q07327; -.
DR BioGRID-ORCS; 38493; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 38493; -.
DR PRO; PR:Q07327; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0004574; Expressed in second segment of antenna (Drosophila) and 48 other tissues.
DR ExpressionAtlas; Q07327; baseline and differential.
DR Genevisible; Q07327; DM.
DR GO; GO:0005737; C:cytoplasm; NAS:FlyBase.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0019898; C:extrinsic component of membrane; IDA:FlyBase.
DR GO; GO:0016020; C:membrane; TAS:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR GO; GO:0043195; C:terminal bouton; IDA:FlyBase.
DR GO; GO:0000149; F:SNARE binding; ISS:FlyBase.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IDA:FlyBase.
DR GO; GO:0006887; P:exocytosis; TAS:FlyBase.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; IMP:FlyBase.
DR GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
DR GO; GO:1900006; P:positive regulation of dendrite development; IMP:FlyBase.
DR GO; GO:0007317; P:regulation of pole plasm oskar mRNA localization; IMP:FlyBase.
DR GO; GO:0009416; P:response to light stimulus; IMP:FlyBase.
DR GO; GO:0032940; P:secretion by cell; IDA:FlyBase.
DR GO; GO:0016082; P:synaptic vesicle priming; NAS:FlyBase.
DR GO; GO:0048489; P:synaptic vesicle transport; TAS:FlyBase.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:FlyBase.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR Gene3D; 3.90.830.10; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR PANTHER; PTHR11679; PTHR11679; 1.
DR Pfam; PF00995; Sec1; 1.
DR PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR SUPFAM; SSF56815; SSF56815; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Membrane; Protein transport; Reference proteome; Transport.
FT CHAIN 1..597
FT /note="Protein ROP"
FT /id="PRO_0000206292"
FT CONFLICT 524
FT /note="S -> L (in Ref. 1; CAA47658/CAA47659)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 597 AA; 67851 MW; A70DB303C743821D CRC64;
MALKVLVGQK LMNEVVKYKP PPPKKQGVTS AAGAGGMEWR VLVVDKLGMR MVSACTKMHE
ISAEGITLVE DINKKREPLP TMDAIYLITP SDESVRGLIR DFENPARPMY RYAHVFFTEV
CPEELFNDLC KSCAAGKIKT LKEINIAFLP YECQVFSLDS PDTFQCLYSP AFASIRSKHI
ERIAEQIATL CATLGEYPNV RYRSDWDRNI DLAASVQQKL DAYKADDATM GEGPEKARSQ
LLILDRGFDC VSPLLHELTL QAMAYDLLPI VNDVYRYTPG PNQPDKEVLL DENDDLWVEL
RHEHIAVVST QVTQNLKKFT DSKRMGSADK SSMRDLSQMI KKMPQYQKEL SKYSTHLHLA
EDCMKSYQNY VDKLCRVEQD LAMGTDAEGE KIKDHMRNIV PILLDANVSN YDKVRIIALY
VMIKNGISEE NLTKLFTHAQ LSPKDQDMVR NLSCLGINVI ADSRKKQYSV PRKERTTEST
YQMSRWTPVI KDIMEDCIED KLDLRHFPFL EGRAQNTNYH APTSARYGHW HKDKGQAQVK
NVPRLIVFIV GGVSMSEMRC AYEVTNAVRN WEVLVGSSHI LSPEIFLSDL GSLSKED
