ID   ROS_AVISU               Reviewed;         402 AA.
AC   P00529;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Tyrosine-protein kinase transforming protein ros;
DE            EC=2.7.10.1;
GN   Name=V-ROS;
OS   UR2 sarcoma virus (UR2SV) (Avian sarcoma virus (strain UR2)).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
OX   NCBI_TaxID=354090;
OH   NCBI_TaxID=8976; Galliformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2983097; DOI=10.1128/jvi.53.3.879-884.1985;
RA   Neckameyer W.S., Wang L.-H.;
RT   "Nucleotide sequence of avian sarcoma virus UR2 and comparison of its
RT   transforming gene with other members of the tyrosine protein kinase
RT   oncogene family.";
RL   J. Virol. 53:879-884(1985).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC   -!- MISCELLANEOUS: This protein is synthesized as a Gag-Ros polyprotein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Insulin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00159}.
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DR   EMBL; M10455; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   PIR; A00635; TVFVUR.
DR   SMR; P00529; -.
DR   PRIDE; P00529; -.
DR   BRENDA; 2.7.10.2; 21388.
DR   Proteomes; UP000143802; Genome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein;
KW   Transferase; Tyrosine-protein kinase.
FT   CHAIN           1..402
FT                   /note="Tyrosine-protein kinase transforming protein ros"
FT                   /id="PRO_0000058927"
FT   DOMAIN          98..377
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        232
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10028"
FT   BINDING         104..112
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         133
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   MOD_RES         268
FT                   /note="Phosphotyrosine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   402 AA;  45073 MW;  B7A955A8D59DB7F8 CRC64;
     DTVTSPDITA IVAVIGAVVL GLTSLTIIIL FGFVWHQRWK SRKPASTGQI VLVKEDKELA
     QLRGMAETVG LANACYAVST LPSQAEIESL PAFPRDKLNL HKLLGSGAFG EVYEGTALDI
     LADGSGESRV AVKTLKRGAT DQEKSEFLKE AHLMSKFDHP HILKLLGVCL LNEPQYLILE
     LMEGGDLLSY LRGARKQKFQ SPLLTLTDLL DICLDICKGC VYLEKMRFIH RDLAARNCLV
     SEKQYGSCSR VVKIGDFGLA RDIYKNDYYR KRGEGLLPVR WMAPESLIDG VFTNHSDVWA
     FGVLVWETLT LGQQPYPGLS NIEVLHHVRS GGRLESPNNC PDDIRDLMTR CWAQDPHNRP
     TFFYIQHKLQ EIRHSPLCFS YFLGDKESVA PLRIQTAFFQ PL