ID   ROT_STAAC               Reviewed;         166 AA.
AC   Q5HF12;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=HTH-type transcriptional regulator rot;
DE   AltName: Full=Repressor of toxins;
GN   Name=rot; OrderedLocusNames=SACOL1812;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
RN   [2]
RP   INDUCTION DURING ANAEROBIC GROWTH.
RX   PubMed=17384184; DOI=10.1128/jb.00081-07;
RA   Fuchs S., Pane-Farre J., Kohler C., Hecker M., Engelmann S.;
RT   "Anaerobic gene expression in Staphylococcus aureus.";
RL   J. Bacteriol. 189:4275-4289(2007).
CC   -!- FUNCTION: Global regulator with both positive and negative effects that
CC       mediates modulation of several genes involved in virulence. Also,
CC       modulates the expression of genes not previously implicated in
CC       pathogenesis (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: Up-regulated during anaerobic growth.
CC       {ECO:0000269|PubMed:17384184}.
CC   -!- SIMILARITY: Belongs to the rot family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW38340.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5HF12; -.
DR   SMR; Q5HF12; -.
DR   EnsemblBacteria; AAW38340; AAW38340; SACOL1812.
DR   KEGG; sac:SACOL1812; -.
DR   HOGENOM; CLU_132118_0_0_9; -.
DR   OMA; LWDKGSM; -.
DR   PRO; PR:Q5HF12; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR016998; Rot.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PIRSF; PIRSF032474; TF_HTH_Rot; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..166
FT                   /note="HTH-type transcriptional regulator rot"
FT                   /id="PRO_0000220544"
FT   DNA_BIND        87..110
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   166 AA;  19431 MW;  251AE45481E5699D CRC64;
     MHKLAHTSFG IVGMFVNTCI VAKYVIINWE MFSMKKVNND TVFGILQLET LLGDINSIFS
     EIESEYKMSR EEILILLTLW QKGFMTLKEM DRFVEVKPYK RTRTYNNLVE LEWIYKERPV
     DDERTVIIHF NEKLQQEKVE LLNFISDAIA SRATAMQNSL NAIIAV