ID   ROT_STAAM               Reviewed;         166 AA.
AC   Q99TA4;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=HTH-type transcriptional regulator rot;
DE   AltName: Full=Repressor of toxins;
GN   Name=rot; OrderedLocusNames=SAV1764;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Global regulator with both positive and negative effects that
CC       mediates modulation of several genes involved in virulence. Also,
CC       modulates the expression of genes not previously implicated in
CC       pathogenesis (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the rot family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB57926.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000017; BAB57926.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q99TA4; -.
DR   SMR; Q99TA4; -.
DR   World-2DPAGE; 0002:Q99TA4; -.
DR   PaxDb; Q99TA4; -.
DR   EnsemblBacteria; BAB57926; BAB57926; SAV1764.
DR   KEGG; sav:SAV1764; -.
DR   HOGENOM; CLU_132118_0_0_9; -.
DR   OMA; LWDKGSM; -.
DR   PRO; PR:Q99TA4; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR016998; Rot.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PIRSF; PIRSF032474; TF_HTH_Rot; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..166
FT                   /note="HTH-type transcriptional regulator rot"
FT                   /id="PRO_0000220545"
FT   DNA_BIND        87..110
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   166 AA;  19389 MW;  D45AB863B323B32C CRC64;
     MHKLAHTSFG IVGMFVNTCM VAKYVIINWE MFSMKKVNND TVFGILQLET LLGDINSIFS
     EIESEYKMSR EEILILLTLW QKGSMTLKEM DRFVEVKPYK RTRTYNNLVE LEWIYKERPV
     DDERTVIIHF NEKLQQEKVE LLNFISDAIA SRATAMQNSL NAIIAV