ROUGH_DROVI
ID ROUGH_DROVI Reviewed; 340 AA.
AC P18264; B4M069;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Homeobox protein rough;
GN Name=ro; ORFNames=GJ22592;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1974051; DOI=10.1073/pnas.87.15.5916;
RA Heberlein U., Rubin G.M.;
RT "Structural and functional comparisons of the Drosophila virilis and
RT Drosophila melanogaster rough genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:5916-5920(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required to establish the unique cell identity of
CC photoreceptors R2 and R5 and consequently for ommatidial assembly in
CC the developing eye imaginal disk. Repression of expression in R8
CC photoreceptor by senseless (sens) is an essential mechanism of R8 cell
CC fate determination (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC Note=Restricted to nuclei in the developing retina. {ECO:0000250}.
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DR EMBL; M35372; AAA28861.1; -; Genomic_DNA.
DR EMBL; CH940650; EDW68319.1; -; Genomic_DNA.
DR PIR; A35967; A35967.
DR RefSeq; XP_002054799.2; XM_002054763.2.
DR AlphaFoldDB; P18264; -.
DR SMR; P18264; -.
DR STRING; 7244.FBpp0237009; -.
DR EnsemblMetazoa; FBtr0438731; FBpp0395458; FBgn0013136.
DR eggNOG; KOG0489; Eukaryota.
DR HOGENOM; CLU_792903_0_0_1; -.
DR InParanoid; P18264; -.
DR OMA; CDTPYHS; -.
DR OrthoDB; 1583482at2759; -.
DR PhylomeDB; P18264; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0042067; P:establishment of ommatidial planar polarity; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0007463; P:R2/R5 cell fate commitment; ISS:UniProtKB.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Sensory transduction; Vision.
FT CHAIN 1..340
FT /note="Homeobox protein rough"
FT /id="PRO_0000049077"
FT DNA_BIND 164..223
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 14
FT /note="Q -> K (in Ref. 1; AAA28861)"
FT /evidence="ECO:0000305"
FT CONFLICT 38
FT /note="I -> M (in Ref. 1; AAA28861)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="A -> G (in Ref. 1; AAA28861)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="L -> V (in Ref. 1; AAA28861)"
FT /evidence="ECO:0000305"
FT CONFLICT 289
FT /note="R -> H (in Ref. 1; AAA28861)"
FT /evidence="ECO:0000305"
FT CONFLICT 310
FT /note="Missing (in Ref. 1; AAA28861)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 37929 MW; 0847083B6EA846DE CRC64;
MLQQNPSSPL HAEQFIKSSN STPTATPAPA SATATAPIHT VLATPQRPSS PRQFFERLYG
HLETRTHNSE SGDIDVGTHA ETPYQSDGGS ASSPDISISD ERVSLVSFPS YELHAPTPDY
SAYGAIANAT LPPALSFPAF SADPHINAGF SAFLARRRRK EGRQRRQRTT FSTEQTLRLE
VEFHRNEYIS RSRRFELAET LRLSETQIKI WFQNRRAKDK RIEKAQIDQH YRNFVVANGF
MSTIMGQTSY ATSAPATSSA AATAAAMLGS SYYAATPALL PSTLVNNARR ADVNYVDIEA
QHQQQQQHHH QVHPDQQQQQ QQQQQRRSRF VPPPTLINSC
