RP1_SAIBB
ID RP1_SAIBB Reviewed; 2149 AA.
AC Q8MJ03;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Oxygen-regulated protein 1;
DE AltName: Full=Retinitis pigmentosa RP1 protein homolog;
GN Name=RP1;
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Malone K.A.;
RT "Comparative sequencing of RP1: a closer look at a highly divergent retina-
RT specific protein.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule-associated protein regulating the stability and
CC length of the microtubule-based axoneme of photoreceptors. Required for
CC the differentiation of photoreceptor cells, it plays a role in the
CC organization of the outer segment of rod and cone photoreceptors
CC ensuring the correct orientation and higher-order stacking of outer
CC segment disks along the photoreceptor axoneme (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via the doublecortin domains) with microtubules.
CC Interacts with RP1L1 (By similarity). Interacts with MAK (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment
CC {ECO:0000250}. Note=Specifically localized in the connecting cilia of
CC rod and cone photoreceptors. {ECO:0000250}.
CC -!- DOMAIN: The doublecortin domains, which mediate interaction with
CC microtubules, are required for regulation of microtubule polymerization
CC and function in photoreceptor differentiation. {ECO:0000250}.
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DR EMBL; AY034787; AAK58444.1; -; mRNA.
DR RefSeq; NP_001266942.1; NM_001280013.1.
DR AlphaFoldDB; Q8MJ03; -.
DR SMR; Q8MJ03; -.
DR STRING; 39432.ENSSBOP00000016672; -.
DR GeneID; 101034977; -.
DR CTD; 6101; -.
DR Proteomes; UP000233220; Whole Genome Shotgun Assembly.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005875; C:microtubule associated complex; ISS:UniProtKB.
DR GO; GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
DR GO; GO:0001750; C:photoreceptor outer segment; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0042461; P:photoreceptor cell development; ISS:UniProtKB.
DR GO; GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
DR GO; GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.
DR GO; GO:0046549; P:retinal cone cell development; ISS:UniProtKB.
DR GO; GO:0046548; P:retinal rod cell development; ISS:UniProtKB.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR Gene3D; 3.10.20.230; -; 2.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR040163; RP1/RP1L1/DCX.
DR PANTHER; PTHR23005; PTHR23005; 1.
DR Pfam; PF03607; DCX; 2.
DR SMART; SM00537; DCX; 2.
DR SUPFAM; SSF89837; SSF89837; 2.
DR PROSITE; PS50309; DC; 2.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Microtubule; Reference proteome; Repeat;
KW Sensory transduction; Vision.
FT CHAIN 1..2149
FT /note="Oxygen-regulated protein 1"
FT /id="PRO_0000097413"
FT DOMAIN 36..118
FT /note="Doublecortin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT DOMAIN 152..231
FT /note="Doublecortin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1435..1456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1442..1456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2149 AA; 239837 MW; 02CDCA902C3A9823 CRC64;
MSDTPSTGFS MIHPTSSEGQ VPSPRHLSLT HPVVAKRISF YKSGDPQFGG VRVVVNPRSF
KSFDALLDNL SRKVPLPFGV RNISTPRGRH SITRLEELED GESYLCSHGR KVQPVDLDKA
RRRPRPWLSS RAVSTHAPPH SVAAPGMPRA PRSLVVFRNG DPKTRRAVLL SRKVTQSFEA
FLQHLTEVMQ RPVVKLYATD GRRVPSLQAV ILSSGAVVAA GREPFKPGNY DIQKYLLPAR
LPGISQRVYP KGNGKSESRK ISTHMASSSR SQIYSVSSEK THNNDCYLDY SFVPENYLAL
EKNDSQNLPI YPSEDDVEKS IIFNQDGTMT VEMKVRFRIK EEETIKWTTT VSKTGPSNND
EKSEMSFPGR TESRSSGLKL AACSFSADVS PTERSSNQEG SLAEEINIQM TDQEAETCSS
ASWENATVDT DIIQGTQDQA KHRFYRPPTP GLRRVRQKKS VIGSVTLVSE TEVQEKMIGQ
FSYSEERESG ENKSEYHMFT HSCSKMSSVS NKPVLVQINN SDQMEESSLE RKKENRLLKS
SAISAGVIEI TSQKMLELSH NNGLPSTISN NSIVEEDVVD SVVSDNKTGI KNLRTYGNTS
DRFSPVSADA THFSSNKSRA DKNISEAPAS VASSTVTARI DRLINEFAQC GLTKLPKTEK
KILSSVASKK KKKKSQQQAI NSRYQDGQLA TTGILNKNER INAGGRITKE MILQDSDSPL
KGGVLCEEDL RTSETVIESN TFCSKSNLNP MISKNFHRNK LNTTQNSKVQ GLLTKRKSRP
LRKISLGTPK KREIGQGDKV FPHNESKYSK STCENKSLFH VFNLLEQKPK HFSGPRSQAE
VASGYLRGMA KKSLVSKVTD SHITLKSQKK QKGDKLKASA ILSKQHAATR ANSLASLKKP
DFPEDIAHPS VQTYIQNWLH NINPYPTLKP IKSAPVCKNE ISVVNCNNSF SGNDPHTSSG
KINNFVMESN KHITKIASLT GDNLCKEGDK SFIANDTGED LCETQVGSLN DAYLVSLHEH
CTSPQSAIND RNTKSRISPE KSGPEINLVY QEINLAKKRQ SVEAAIQVDP IEEDTPKDLL
PVLMLHQLQA SVPSTPKTQN GVVRMPGSLA DVSFPSAICN SSTNLLLAWL LVLNLKGSMN
SFCQGDAHKT TNKSSETLAL LEILKHIAIT EEADDLKAAV ANLVESTTNH FGLSEKEQDT
VPIDLSANCS IVNIQSVPKC NENEGTQGIF SFDGGCSAVE ACAPEVCVLE LTYPPREVCT
VNKAYVPKET CNLSDTFFPS DGYTVDRTSM NKACFVGEVC SLTDTVFSDK ACAQKENHIY
EGACATDETC VPVDVCNTTG FLNSKQNTYT DNLESTEELE RGDDVQKDLN ILTDPEYKNG
FNTLVSHQNV SNLSPCGLCV SEEAEFDKKH SSADDFKNCS LNLFQDKNAY TSFDMEEPRT
SEEPGSVTNS VTSSERNISE LESFEELENQ DTDIFNTEIN VGEKATEEFI QEEIEASKTL
ELLDISSKNI MVEERKNGII YETISKRLAT PPSLVFCYDS KQNNEKETNE GETNMVKMMV
KSMETGSYSE SSPDMKKCIK SPVTSDWSDY RPDSDSEQAY KTSSDDPNDS GELEKEYNIG
FVKRAIEKLY GKADIIKPSF FPGSTRKSQV CPYNSVEFQC TRRASLYDSE GQSFGSSERV
SSSSPVLQEF QEEGQDKCDI NHVRNNYCGG DIVEPGTKEN DHSRVLTDIE EGVLIDKGKW
LLKENHLLRM SYENPGVCGN ADTTSVDTLL DNNSSEVPYS HFGNLAPGPT MDELSSSELE
ELTQPLELKC NYFKMPHGSD SEPFHEDLLG VHNETCDKER IANHHTEEKC PHQSERICTS
VTHSFMSAGN KVYPVSDDAI KNQPLPGSNM IHGTLQETDS LDKLYALCGQ HCPILTVTIQ
PVNEEDRGFA YRKESDIENF LGFYLWMKIH PYLLQTDKNM FREENNKASM RKNLINNATG
DIFDEFYFSN IFDLMDKRRK QKRINFLELQ EAGNLKKFQP DLKERFCMYF LHTSSLVVGN
MNSNTQDLSS QTNEIFKAVD ENNNLLNNRF QGSRTNLNQV VRENISRYFF EMLGQACLLD
ICQVETSLNI SNRNILEELC MFEDENIFIW EEEDILNLTD LESSREQDL