RP25L_HUMAN
ID RP25L_HUMAN Reviewed; 163 AA.
AC Q8N5L8; D3DRM5;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Ribonuclease P protein subunit p25-like protein;
DE Short=RNase P protein subunit-like p25;
DE AltName: Full=Rpp25-like protein;
GN Name=RPP25L; Synonyms=C9orf23;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHYLOGENY.
RX PubMed=16998185; DOI=10.1093/nar/gkl626;
RA Rosenblad M.A., Lopez M.D., Piccinelli P., Samuelsson T.;
RT "Inventory and analysis of the protein subunits of the ribonucleases P and
RT MRP provides further evidence of homology between the yeast and human
RT enzymes.";
RL Nucleic Acids Res. 34:5145-5156(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be a component of ribonuclease P or MRP.
CC -!- INTERACTION:
CC Q8N5L8; Q92974: ARHGEF2; NbExp=7; IntAct=EBI-10189722, EBI-302405;
CC Q8N5L8; Q53G59: KLHL12; NbExp=6; IntAct=EBI-10189722, EBI-740929;
CC Q8N5L8; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10189722, EBI-10172526;
CC Q8N5L8; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-10189722, EBI-302345;
CC Q8N5L8; O75817: POP7; NbExp=12; IntAct=EBI-10189722, EBI-366574;
CC Q8N5L8; Q96KN7: RPGRIP1; NbExp=3; IntAct=EBI-10189722, EBI-1050213;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the histone-like Alba family. {ECO:0000305}.
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DR EMBL; AL160270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471071; EAW58443.1; -; Genomic_DNA.
DR EMBL; CH471071; EAW58444.1; -; Genomic_DNA.
DR EMBL; BC032136; AAH32136.1; -; mRNA.
DR CCDS; CCDS6559.1; -.
DR RefSeq; NP_680544.1; NM_148178.2.
DR RefSeq; NP_680545.1; NM_148179.2.
DR AlphaFoldDB; Q8N5L8; -.
DR SMR; Q8N5L8; -.
DR BioGRID; 126519; 71.
DR IntAct; Q8N5L8; 25.
DR MINT; Q8N5L8; -.
DR STRING; 9606.ENSP00000297613; -.
DR iPTMnet; Q8N5L8; -.
DR PhosphoSitePlus; Q8N5L8; -.
DR BioMuta; RPP25L; -.
DR DMDM; 74751030; -.
DR EPD; Q8N5L8; -.
DR jPOST; Q8N5L8; -.
DR MassIVE; Q8N5L8; -.
DR MaxQB; Q8N5L8; -.
DR PaxDb; Q8N5L8; -.
DR PeptideAtlas; Q8N5L8; -.
DR PRIDE; Q8N5L8; -.
DR ProteomicsDB; 72072; -.
DR Antibodypedia; 55898; 80 antibodies from 15 providers.
DR DNASU; 138716; -.
DR Ensembl; ENST00000297613.4; ENSP00000297613.4; ENSG00000164967.10.
DR Ensembl; ENST00000378959.9; ENSP00000368242.4; ENSG00000164967.10.
DR GeneID; 138716; -.
DR KEGG; hsa:138716; -.
DR MANE-Select; ENST00000378959.9; ENSP00000368242.4; NM_148178.3; NP_680544.1.
DR UCSC; uc003zuu.4; human.
DR CTD; 138716; -.
DR GeneCards; RPP25L; -.
DR HGNC; HGNC:19909; RPP25L.
DR HPA; ENSG00000164967; Tissue enhanced (skeletal).
DR neXtProt; NX_Q8N5L8; -.
DR OpenTargets; ENSG00000164967; -.
DR PharmGKB; PA134989644; -.
DR VEuPathDB; HostDB:ENSG00000164967; -.
DR eggNOG; KOG2567; Eukaryota.
DR GeneTree; ENSGT00390000002564; -.
DR HOGENOM; CLU_096311_0_0_1; -.
DR InParanoid; Q8N5L8; -.
DR OMA; HQYTQLG; -.
DR OrthoDB; 1075123at2759; -.
DR PhylomeDB; Q8N5L8; -.
DR TreeFam; TF325688; -.
DR PathwayCommons; Q8N5L8; -.
DR SignaLink; Q8N5L8; -.
DR BioGRID-ORCS; 138716; 200 hits in 1087 CRISPR screens.
DR ChiTaRS; RPP25L; human.
DR GenomeRNAi; 138716; -.
DR Pharos; Q8N5L8; Tdark.
DR PRO; PR:Q8N5L8; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8N5L8; protein.
DR Bgee; ENSG00000164967; Expressed in tibialis anterior and 178 other tissues.
DR Genevisible; Q8N5L8; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000172; C:ribonuclease MRP complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IBA:GO_Central.
DR Gene3D; 3.30.110.20; -; 1.
DR InterPro; IPR036882; Alba-like_dom_sf.
DR InterPro; IPR002775; DNA/RNA-bd_Alba-like.
DR Pfam; PF01918; Alba; 1.
DR SUPFAM; SSF82704; SSF82704; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..163
FT /note="Ribonuclease P protein subunit p25-like protein"
FT /id="PRO_0000271032"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 163 AA; 17631 MW; 442C8727191A0BCE CRC64;
MEHYRKAGSV ELPAPSPMPQ LPPDTLEMRV RDGSKIRNLL GLALGRLEGG SARHVVFSGS
GRAAGKAVSC AEIVKRRVPG LHQLTKLRFL QTEDSWVPAS PDTGLDPLTV RRHVPAVWVL
LSRDPLDPNE CGYQPPGAPP GLGSMPSSSC GPRSRRRARD TRS
