RP25L_MOUSE
ID RP25L_MOUSE Reviewed; 163 AA.
AC Q99JH1; Q9CYX4;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Ribonuclease P protein subunit p25-like protein;
DE Short=RNase P protein subunit-like p25;
DE AltName: Full=Rpp25-like protein;
GN Name=Rpp25l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RA Ievolella C., Zara I., Lanfranchi G.;
RT "Full length sequencing of some human and murine muscular transcript
RT (Telethon Italy project B41).";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be a component of ribonuclease P or MRP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone-like Alba family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ293897; CAC34588.1; -; mRNA.
DR EMBL; AK013222; BAB28723.1; -; mRNA.
DR EMBL; BC047068; AAH47068.1; -; mRNA.
DR CCDS; CCDS18068.1; -.
DR RefSeq; NP_081554.2; NM_027278.3.
DR AlphaFoldDB; Q99JH1; -.
DR SMR; Q99JH1; -.
DR STRING; 10090.ENSMUSP00000041477; -.
DR iPTMnet; Q99JH1; -.
DR PhosphoSitePlus; Q99JH1; -.
DR EPD; Q99JH1; -.
DR MaxQB; Q99JH1; -.
DR PaxDb; Q99JH1; -.
DR PeptideAtlas; Q99JH1; -.
DR PRIDE; Q99JH1; -.
DR ProteomicsDB; 260918; -.
DR Antibodypedia; 55898; 80 antibodies from 15 providers.
DR Ensembl; ENSMUST00000038434; ENSMUSP00000041477; ENSMUSG00000036114.
DR GeneID; 69961; -.
DR KEGG; mmu:69961; -.
DR UCSC; uc008sjh.2; mouse.
DR CTD; 138716; -.
DR MGI; MGI:1917211; Rpp25l.
DR VEuPathDB; HostDB:ENSMUSG00000036114; -.
DR eggNOG; KOG2567; Eukaryota.
DR GeneTree; ENSGT00390000002564; -.
DR HOGENOM; CLU_096311_0_0_1; -.
DR InParanoid; Q99JH1; -.
DR OMA; GRPLCRQ; -.
DR OrthoDB; 1075123at2759; -.
DR PhylomeDB; Q99JH1; -.
DR TreeFam; TF325688; -.
DR BioGRID-ORCS; 69961; 22 hits in 71 CRISPR screens.
DR ChiTaRS; Rpp25l; mouse.
DR PRO; PR:Q99JH1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q99JH1; protein.
DR Bgee; ENSMUSG00000036114; Expressed in hindlimb stylopod muscle and 252 other tissues.
DR Genevisible; Q99JH1; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000172; C:ribonuclease MRP complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IBA:GO_Central.
DR Gene3D; 3.30.110.20; -; 1.
DR InterPro; IPR036882; Alba-like_dom_sf.
DR InterPro; IPR002775; DNA/RNA-bd_Alba-like.
DR Pfam; PF01918; Alba; 1.
DR SUPFAM; SSF82704; SSF82704; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..163
FT /note="Ribonuclease P protein subunit p25-like protein"
FT /id="PRO_0000271033"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..147
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 6
FT /note="R -> E (in Ref. 2; BAB28723)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 163 AA; 17675 MW; 87675201AF87F5B6 CRC64;
MEQYRRAGSV ELPASSPMPQ LPPDTLEMRV RDGSKIRNLL GLALGRLEGG STRHVVFSGS
GRAAGKAVSC AEIVKRRVPG LHQLTKLRFL QTEDSWVPTS PDTGLDPLTV RRHVPAVWVL
LSRDPLDPSE CGYQPPGAPP GLGSIPSPSC GPRPRRRARD TRS
