ID   RP43_RIFPA              Reviewed;         421 AA.
AC   Q9NH13;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Exoskeleton protein RP43;
DE   Flags: Precursor;
OS   Riftia pachyptila (Vent tube worm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC   Sedentaria; Canalipalpata; Sabellida; Siboglinidae; Riftia.
OX   NCBI_TaxID=6426;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAF37867.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-41; 108-115; 158-172;
RP   305-323 AND 413-420, AND TISSUE SPECIFICITY.
RX   PubMed=10947956; DOI=10.1042/bj3500421;
RA   Chamoy L., Nicolai M., Quennedey B., Gaill F., Delachambre J.;
RT   "Characterization of a cDNA encoding RP43, a CUB-domain-containing protein
RT   from the tube of Riftia pachyptila (Vestimentifera), and distribution of
RT   its transcript.";
RL   Biochem. J. 350:421-427(2000).
CC   -!- FUNCTION: May play a role in protein-protein interactions during tube
CC       assembly. {ECO:0000269|PubMed:10947956}.
CC   -!- TISSUE SPECIFICITY: Detected in vestimentum and trunk but not in
CC       opisthosome or obturaculum. In the vestimentum, expression is
CC       restricted to epithelial cells under apical cuticular plaques.
CC       {ECO:0000269|PubMed:10947956}.
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DR   EMBL; AF233595; AAF37867.1; -; mRNA.
DR   AlphaFoldDB; Q9NH13; -.
DR   SMR; Q9NH13; -.
DR   GO; GO:0006033; P:chitin localization; NAS:UniProtKB.
DR   GO; GO:0030198; P:extracellular matrix organization; NAS:UniProtKB.
DR   CDD; cd00041; CUB; 3.
DR   Gene3D; 2.60.120.290; -; 3.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 3.
DR   SMART; SM00042; CUB; 3.
DR   SUPFAM; SSF49854; SSF49854; 3.
DR   PROSITE; PS01180; CUB; 3.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Repeat; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..421
FT                   /note="Exoskeleton protein RP43"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000233939"
FT   DOMAIN          72..191
FT                   /note="CUB 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DOMAIN          193..306
FT                   /note="CUB 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DOMAIN          309..421
FT                   /note="CUB 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DISULFID        72..104
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DISULFID        132..154
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DISULFID        193..219
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DISULFID        247..269
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DISULFID        309..335
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT   DISULFID        362..384
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
SQ   SEQUENCE   421 AA;  47043 MW;  84C1926F5E9790E8 CRC64;
     MRVIFVISLV SFMFVTWQTN PVHCRQHKTP QVVDLGYSGA KVETVMKTSD VVYAKPMCHG
     GRCPPPPPTK TCSKPSSLKA VSRAGHAGYF GTIGSGKYKN NENCWWSIQA PADQRLRLHF
     ESLYLEYGNR YCPYDYVNIH NGKNENGQRL GKYCGIKAPD DIITTGNSAY VRFSTDSSVT
     KYGFRLRYSI VSCNSLHTIF GSHGEFGTVG PAYGNFEECS WKIEVPNGKR VRLHFKRFHL
     ENNNKYCPYD KLKIYDGSSA SASLKGTLCG KRRPKDIEST GKTMFVTFSS DISLTFPGFR
     IQYSVPASCS VVNELTGPSG TFGTTGSQYE NNEVCSWKIE VAQNKRVLLH IYRFNIEVEA
     NCEYDSLTVY KGPNDSAPML GKYCGETIPT FMVSSGNTMF IKFQTDGSAR KPGFWIGYTT
     G