ID   RP54_HELPY              Reviewed;         414 AA.
AC   P56143;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=RNA polymerase sigma-54 factor;
GN   Name=rpoN; OrderedLocusNames=HP_0714;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released.
CC   -!- SIMILARITY: Belongs to the sigma-54 factor family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07764.1; -; Genomic_DNA.
DR   PIR; B64609; B64609.
DR   RefSeq; NP_207508.1; NC_000915.1.
DR   RefSeq; WP_000996418.1; NC_018939.1.
DR   AlphaFoldDB; P56143; -.
DR   SMR; P56143; -.
DR   DIP; DIP-3064N; -.
DR   IntAct; P56143; 11.
DR   MINT; P56143; -.
DR   STRING; 85962.C694_03675; -.
DR   PaxDb; P56143; -.
DR   EnsemblBacteria; AAD07764; AAD07764; HP_0714.
DR   KEGG; hpy:HP_0714; -.
DR   PATRIC; fig|85962.47.peg.763; -.
DR   eggNOG; COG1508; Bacteria.
DR   OMA; NPPAIEF; -.
DR   PhylomeDB; P56143; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IEA:InterPro.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.1330; -; 1.
DR   InterPro; IPR000394; RNA_pol_sigma_54.
DR   InterPro; IPR007046; RNA_pol_sigma_54_core-bd.
DR   InterPro; IPR007634; RNA_pol_sigma_54_DNA-bd.
DR   InterPro; IPR038709; RpoN_core-bd_sf.
DR   PANTHER; PTHR32248; PTHR32248; 1.
DR   Pfam; PF00309; Sigma54_AID; 1.
DR   Pfam; PF04963; Sigma54_CBD; 1.
DR   Pfam; PF04552; Sigma54_DBD; 1.
DR   PIRSF; PIRSF000774; RpoN; 1.
DR   PRINTS; PR00045; SIGMA54FCT.
DR   TIGRFAMs; TIGR02395; rpoN_sigma; 1.
DR   PROSITE; PS00717; SIGMA54_1; 1.
DR   PROSITE; PS00718; SIGMA54_2; 1.
DR   PROSITE; PS50044; SIGMA54_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding; DNA-directed RNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Sigma factor; Transcription; Transcription regulation;
KW   Transferase.
FT   CHAIN           1..414
FT                   /note="RNA polymerase sigma-54 factor"
FT                   /id="PRO_0000205531"
FT   DNA_BIND        301..320
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOTIF           387..395
FT                   /note="RPON box"
SQ   SEQUENCE   414 AA;  48173 MW;  C7781CE32B5B04FE CRC64;
     MAILRANLSP KNKLNATLKG WLPILQSELE DLEEVLKQNA LDNPLIKIEN KRIKNFSDRF
     SAKKSSDHLE NFATASKSLF ETLEAQIIPP LFPTETSQKI AMDIISGLNN EGYFEENIEE
     RARILGVESE VYEKVRKRFS YLNPAGIGAK DVKESFLFQL ESRELDDNEL YEETRKIILN
     LEKHHEFSKD FYYEKALKIL KSFKNPPAIE FLEKEIEVIP ELFIVEVDNG IIVRLNDESY
     PTISLEENRF KDSGYLKEKL KEAKDLIDAL NLRKATIYKI GLMLLEYQYD FFKGKELRPL
     KLLDLANEFN HSVSTISRAI SNKYLACERG VFPIKHFFSI ALDNSETSNA VIKDYLLELI
     KNEDKKEPLS DAKILELIEE KFHLKMVRRT ITKYRQLLNI ASSSERKRLY LMRA