ID   RP54_TREPA              Reviewed;         475 AA.
AC   O83149;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=RNA polymerase sigma-54 factor;
GN   Name=rpoN; OrderedLocusNames=TP_0111;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sigma-54 factor family. {ECO:0000305}.
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DR   EMBL; AE000520; AAC65101.1; -; Genomic_DNA.
DR   PIR; F71364; F71364.
DR   AlphaFoldDB; O83149; -.
DR   IntAct; O83149; 2.
DR   STRING; 243276.TPANIC_0111; -.
DR   EnsemblBacteria; AAC65101; AAC65101; TP_0111.
DR   KEGG; tpa:TP_0111; -.
DR   eggNOG; COG1508; Bacteria.
DR   HOGENOM; CLU_020569_0_1_12; -.
DR   OMA; VTTQKFM; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IEA:InterPro.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   InterPro; IPR000394; RNA_pol_sigma_54.
DR   InterPro; IPR007046; RNA_pol_sigma_54_core-bd.
DR   InterPro; IPR007634; RNA_pol_sigma_54_DNA-bd.
DR   PANTHER; PTHR32248; PTHR32248; 1.
DR   Pfam; PF00309; Sigma54_AID; 1.
DR   Pfam; PF04963; Sigma54_CBD; 1.
DR   Pfam; PF04552; Sigma54_DBD; 1.
DR   PIRSF; PIRSF000774; RpoN; 1.
DR   TIGRFAMs; TIGR02395; rpoN_sigma; 1.
DR   PROSITE; PS00717; SIGMA54_1; 1.
DR   PROSITE; PS00718; SIGMA54_2; 1.
DR   PROSITE; PS50044; SIGMA54_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding; DNA-directed RNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Sigma factor; Transcription; Transcription regulation;
KW   Transferase.
FT   CHAIN           1..475
FT                   /note="RNA polymerase sigma-54 factor"
FT                   /id="PRO_0000205545"
FT   DNA_BIND        356..375
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   MOTIF           458..466
FT                   /note="RPON box"
SQ   SEQUENCE   475 AA;  54280 MW;  2464059A019A6190 CRC64;
     MQQLVQQQRL VLNQRLVHGL CLLQLSRGDL KTEVLRAVQR NPLLEIRPSS ARRTGKACYL
     SLGDRRERMR ARDRFQQLLE NQPDKQVDNI RAVLREQVFY QKHEAIVLDL ACAFIQMLDD
     HGFFSISPAI FQNMCGSMPT ALQEKIPQAI ALIQRLEPQG CAVFNFKESL AVQARLRFER
     FSDPLYRCVI NLLTHHSELL FCSDNMCDGR VSVHALTTQI NSMGLCVQKV SSNDVKDILL
     LIKELHPFPG KCVSNAQRAD TNMLLEPDVL ITKTAHGFVT QINCTGIPTV VFRNDYCMHS
     KAAEKNHALK ACMHDALSLV SMLSYRERTL LDIAKTIVHY QCGFFDHGPA KLTPLRMTDV
     AHRTGLSVST VSRIVRDKWL QYGSQHFSLR YFFSPRVLST EEYRDRSSLG QNYPSSPHSK
     VSVKYRISRL IQEVRTQRIS LSDRRIAQLL GEQGIKCARR TVNKYRSELR TCSSS