ID   RP8HA_ARATH             Reviewed;         910 AA.
AC   P59584;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   11-APR-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Disease resistance protein RPH8A;
DE   AltName: Full=RPP8 homolog A;
GN   Name=RPH8A;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND FUNCTION.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=9811794; DOI=10.2307/3870909;
RA   McDowell J.M., Dhandaydham M., Long T.A., Aarts M.G.M., Goff S.,
RA   Holub E.B., Dangl J.L.;
RT   "Intragenic recombination and diversifying selection contribute to the
RT   evolution of downy mildew resistance at the RPP8 locus of Arabidopsis.";
RL   Plant Cell 10:1861-1874(1998).
CC   -!- FUNCTION: Disease resistance protein. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth. In contrast to RPP8, it does not specifically
CC       recognize the Emco5 avirulence protein from Hyaloperonospora
CC       parasitica. {ECO:0000269|PubMed:9811794}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family. RPP8/HRT
CC       subfamily. {ECO:0000305}.
CC   -!- CAUTION: In cv. Columbia and cv. Di-17, this protein is not present due
CC       to an unequal crossing over between the RPP8 and RP8HA genes that
CC       creates a unique RPP8 gene. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   AlphaFoldDB; P59584; -.
DR   SMR; P59584; -.
DR   ExpressionAtlas; P59584; baseline and differential.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Hypersensitive response; Nucleotide-binding;
KW   Plant defense; Repeat.
FT   CHAIN           1..910
FT                   /note="Disease resistance protein RPH8A"
FT                   /id="PRO_0000212720"
FT   DOMAIN          146..459
FT                   /note="NB-ARC"
FT   COILED          15..57
FT                   /evidence="ECO:0000255"
FT   BINDING         192..199
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   910 AA;  105264 MW;  5B1E9F65A19A12EE CRC64;
     MAEGFVSFGL EKLWDLLSRE SERLQGIDEQ LDGLKRQLRS LQSLLKDADA KKHGSDRVRN
     FLEDVKDLVF DAEDIIESYV LNKLRGEGKG VKKHVRRLAR FLTDRHKVAS DIEGITKRIS
     EVIGEMQSFG IQQIIDGGRS LSLQERQRVQ REIRQTYPDS SESDLVGVEQ SVTELVCHLV
     ENDVHQVVSI AGMGGIGKTT LARQVFHHDL VRRHFDGFAW VCVSQQFTQK HVWQRILQEL
     QPHDGEILQM DEYTIQGKLF QLLETGRYLV VLDDVWKKED WDRIKAVFPR KRGWKMLLTS
     RNEGVGIHAD PTCLTFRASI LNPEESWKLC ERIVFPRRDE TEVRLDEEME AMGKEMVTHC
     GGLPLAVKAL GGLLANKHTV PEWKRVSDNI GSQIVGGSCL DDNSLNSVYR ILSLSYEDLP
     THLKHCFLHL AHYPEDSKIY TQDLFNYWAA EGIYDGSTIQ DSGEYYLEEL VRRNLVIADN
     RYLISEFKIK NCQMHDMMRE VCLSKAKEEN FLQIIKDPTC TSTINAQSPS RSRRLSIHSG
     KAFHILGHKR NAKVRSLIVS RFEEDFWIRS ASVFHNLTLL RVLDLSWVKF EGGKLPCSIG
     GLIHLRYLRL YGAVVSHLPS TMRNLKLLLY LNLSVHNEDL IHVPNVLKEM IELRYLSIPV
     KMDDKTKLEL GDLVNLEYLY GFSTQHTSVT DLLRMTKLRN LTVSLSERYN FKTLSSSLRE
     LRNLETLYVL FSRKTYMVDH MGEFVLDHFI HLKELGLVVR MSKIPDQHQF PPHLVHIFLF
     YCGMEEDPMP ILEKLHHLKS VQLRYKAFVG RRMVCSKDGF TQLCALDISK QSELEDWIVE
     EGSMPCLRTL TIHDCEKLKE LPDGLKYITS LKELKIEGMK REWKEKLVPG GEDYYKVQHI
     PDVQFINCDQ