ID   RP8L2_ARATH             Reviewed;         906 AA.
AC   P0C8S1; F4HRG3; O64976; Q9MAG6;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Probable disease resistance RPP8-like protein 2;
GN   Name=RPP8L2; OrderedLocusNames=At1g53350; ORFNames=F12M16.35;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-356.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=9530866; DOI=10.1094/mpmi.1998.11.4.251;
RA   Aarts M.G.M., te Lintel Hekkert B., Holub E.B., Beynon J.L., Stiekema W.J.,
RA   Pereira A.;
RT   "Identification of R-gene homologous DNA fragments genetically linked to
RT   disease resistance loci in Arabidopsis thaliana.";
RL   Mol. Plant Microbe Interact. 11:251-258(1998).
CC   -!- FUNCTION: Potential disease resistance protein.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family. RPP8/HRT
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF69538.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g53350 and At1g53360.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC008007; AAF69538.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE32929.2; -; Genomic_DNA.
DR   EMBL; AF039382; AAC14558.1; -; Genomic_DNA.
DR   PIR; F96573; F96573.
DR   RefSeq; NP_001319213.1; NM_001333589.1.
DR   AlphaFoldDB; P0C8S1; -.
DR   SMR; P0C8S1; -.
DR   BioGRID; 26996; 1.
DR   STRING; 3702.AT1G53350.1; -.
DR   iPTMnet; P0C8S1; -.
DR   PaxDb; P0C8S1; -.
DR   PRIDE; P0C8S1; -.
DR   ProteomicsDB; 228221; -.
DR   EnsemblPlants; AT1G53350.1; AT1G53350.1; AT1G53350.
DR   GeneID; 841771; -.
DR   Gramene; AT1G53350.1; AT1G53350.1; AT1G53350.
DR   KEGG; ath:AT1G53350; -.
DR   Araport; AT1G53350; -.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000837_25_4_1; -.
DR   InParanoid; P0C8S1; -.
DR   OMA; DEVWNPL; -.
DR   OrthoDB; 164862at2759; -.
DR   PhylomeDB; P0C8S1; -.
DR   PRO; PR:P0C8S1; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; P0C8S1; baseline and differential.
DR   Genevisible; P0C8S1; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..906
FT                   /note="Probable disease resistance RPP8-like protein 2"
FT                   /id="PRO_0000212722"
FT   DOMAIN          144..454
FT                   /note="NB-ARC"
FT   REPEAT          573..597
FT                   /note="LRR 1"
FT   REPEAT          598..621
FT                   /note="LRR 2"
FT   REPEAT          623..644
FT                   /note="LRR 3"
FT   REPEAT          646..671
FT                   /note="LRR 4"
FT   REPEAT          672..696
FT                   /note="LRR 5"
FT   REPEAT          704..727
FT                   /note="LRR 6"
FT   REPEAT          740..766
FT                   /note="LRR 7"
FT   REPEAT          767..790
FT                   /note="LRR 8"
FT   REPEAT          791..818
FT                   /note="LRR 9"
FT   REPEAT          840..865
FT                   /note="LRR 10"
FT   COILED          15..68
FT                   /evidence="ECO:0000255"
FT   BINDING         190..197
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        248
FT                   /note="M -> T (in Ref. 3; AAC14558)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        339
FT                   /note="T -> TA (in Ref. 3; AAC14558)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   906 AA;  104063 MW;  E6FDF4A8FE398D0B CRC64;
     MAEAVVSFGV EKLWELLSRE SARLNGIDEQ VDGLKRQLGR LQSLLKDADA KKNETERVRN
     FLEDVKDIVY DADDIIESFL LNELRGKEKG IKKQVRTLAC FLVDRRKFAS DIEGITKRIS
     EVIVGMQSLG IQHIADGGGR SLSLQERQRE IRQTFSRNSE SDLVGLDQSV EELVDHLVEN
     DSVQVVSVSG MGGIGKTTLA RQVFHHDIVR RHFDGFSWVC VSQQFTRKDV WQRILQDLRP
     YDEGIIQMDE YTLQGELFEL LESGRYLLVL DDVWKEEDWD RIKAVFPHKR GWKMLLTSRN
     EGLGLHADPT CFAFRPRILT PEQSWKLFER IVSSRRDKTE FKVDEAMGKE MVTYCGGLPL
     AVKVLGGLLA KKHTVLEWKR VHSNIVTHIV GKSGLSDDNS NSVYRVLSLS YEDLPMQLKH
     CFFYLAHFPE DYKIDVKILF NYWVAEGIIT PFHDGSTIQD TGESYLEELV RRNMVVVEES
     YLTSRIEYCQ MHDMMREVCL SKAKEENFIR VVKVPTTTST TINAQSPCRS RRLVLHSGNA
     LHMLGHKDNK KARSVLIFGV EEKFWKPRGF QCLPLLRVLD LSYVQFEGGK LPSSIGDLIH
     LRFLSLYEAG VSHLPSSLGN LKLLLCLNLG VADRLLVHVP NVLKEMQELR YLRLPRSMPA
     KTKLELGDLV NLESLTNFST KHGSVTDLLR MTKLSVLNVI FSGECTFETL LLSLRELRNL
     ETLSFHDFQK VSVANHGGEL LVLDFIHLKD LTLSMHLPRF PDQYRFPPHL AHIWLIGCRM
     EEDPMPILEK LLHLKSVYLS SGAFLGRRMV CSKGGFPQLL ALKMSYKKEL VEWRVEEGSM
     PCLRTLTIDN CKKLKQLPDG LKYVTCLKEL KIERMKREWT ERLVIGGEDY YKVQHIPSVQ
     FINCDH