ID   RP8L3_ARATH             Reviewed;         901 AA.
AC   Q9FJB5; O64978; O64979; Q0WUX1;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Disease resistance RPP8-like protein 3;
GN   Name=RPP8L3; OrderedLocusNames=At5g35450; ORFNames=K21B8.10, MOK9.3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA   Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT   features of the regions of 1,013,767 bp covered by sixteen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:297-308(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 453-581 AND 772-901.
RX   PubMed=9530866; DOI=10.1094/mpmi.1998.11.4.251;
RA   Aarts M.G.M., te Lintel Hekkert B., Holub E.B., Beynon J.L., Stiekema W.J.,
RA   Pereira A.;
RT   "Identification of R-gene homologous DNA fragments genetically linked to
RT   disease resistance loci in Arabidopsis thaliana.";
RL   Mol. Plant Microbe Interact. 11:251-258(1998).
CC   -!- FUNCTION: Disease resistance protein.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family. RPP8/HRT
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC14261.1; Type=Frameshift; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AB015477; BAB08703.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED93968.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM70947.1; -; Genomic_DNA.
DR   EMBL; AK227013; BAE99077.1; -; mRNA.
DR   EMBL; AH006046; AAC14262.1; -; Genomic_DNA.
DR   EMBL; AH006046; AAC14261.1; ALT_FRAME; Genomic_DNA.
DR   RefSeq; NP_001332515.1; NM_001344104.1.
DR   RefSeq; NP_198395.1; NM_122936.5.
DR   AlphaFoldDB; Q9FJB5; -.
DR   SMR; Q9FJB5; -.
DR   STRING; 3702.AT5G35450.1; -.
DR   iPTMnet; Q9FJB5; -.
DR   PaxDb; Q9FJB5; -.
DR   PRIDE; Q9FJB5; -.
DR   ProteomicsDB; 227978; -.
DR   EnsemblPlants; AT5G35450.1; AT5G35450.1; AT5G35450.
DR   EnsemblPlants; AT5G35450.2; AT5G35450.2; AT5G35450.
DR   GeneID; 833508; -.
DR   Gramene; AT5G35450.1; AT5G35450.1; AT5G35450.
DR   Gramene; AT5G35450.2; AT5G35450.2; AT5G35450.
DR   KEGG; ath:AT5G35450; -.
DR   Araport; AT5G35450; -.
DR   TAIR; locus:2169523; AT5G35450.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000837_25_4_1; -.
DR   InParanoid; Q9FJB5; -.
DR   OMA; HISLRIC; -.
DR   OrthoDB; 164862at2759; -.
DR   PhylomeDB; Q9FJB5; -.
DR   PRO; PR:Q9FJB5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FJB5; baseline and differential.
DR   Genevisible; Q9FJB5; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..901
FT                   /note="Disease resistance RPP8-like protein 3"
FT                   /id="PRO_0000212723"
FT   DOMAIN          144..453
FT                   /note="NB-ARC"
FT   REPEAT          567..591
FT                   /note="LRR 1"
FT   REPEAT          592..615
FT                   /note="LRR 2"
FT   REPEAT          833..858
FT                   /note="LRR 3"
FT   COILED          15..56
FT                   /evidence="ECO:0000255"
FT   BINDING         190..197
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         385..392
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        453..460
FT                   /note="ILDSGEDY -> DGGGGEND (in Ref. 4; AAC14262)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        810
FT                   /note="P -> L (in Ref. 4; AAC14261)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        862
FT                   /note="E -> R (in Ref. 4; AAC14261)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   901 AA;  103767 MW;  0D1F1512C11AF8C7 CRC64;
     MAEGVVSFGV QKLWALLNRE SERLNGIDEQ VDGLKRQLRG LQSLLKDADA KKHGSDRVRN
     FLEDVKDLVF DAEDIIESYV LNKLRGEGKG VKNHVRRLAC FLTDRHKVAS DIEGITKRIS
     KVIGEMQSLG IQQQIIDGGR SLSLQDIQRE IRQTFPNSSE SDLVGVEQSV EELVGPMVEI
     DNIQVVSISG MGGIGKTTLA RQIFHHDLVR RHFDGFAWVC VSQQFTQKHV WQRILQELRP
     HDGEILQMDE YTIQGKLFQL LETGRYLVVL DDVWKEEDWD RIKEVFPRKR GWKMLLTSRN
     EGVGLHADPT CLSFRARILN PKESWKLFER IVPRRNETEY EEMEAIGKEM VTYCGGLPLA
     VKVLGGLLAN KHTASEWKRV SENIGAQIVG KSCLDDNSLN SVYRILSLSY EDLPTDLKHC
     FLYLAHFPED YKIKTRTLYS YWAAEGIYDG LTILDSGEDY LEELVRRNLV IAEKSNLSWR
     LKLCQMHDMM REVCISKAKV ENFLQIIKVP TSTSTIIAQS PSRSRRLTVH SGKAFHILGH
     KKKVRSLLVL GLKEDLWIQS ASRFQSLPLL RVLDLSSVKF EGGKLPSSIG GLIHLRFLSL
     HQAVVSHLPS TIRNLKLMLY LNLHVAIGVP VHVPNVLKEM LELRYLSLPL DMHDKTKLEL
     GDLVNLEYLW CFSTQHSSVT DLLRMTKLRF FGVSFSERCT FENLSSSLRQ FRKLETLSFI
     YSRKTYMVDY VGEFVLDFIH LKKLSLGVHL SKIPDQHQLP PHIAHIYLLF CHMEEDPMPI
     LEKLLHLKSV ELRRKAFIGR RMVCSKGGFP QLRALQISEQ SELEEWIVEE GSMPCLRDLI
     IHSCEKLEEL PDGLKYVTSL KELKIEGMKR EWKEKLVGED YYKVQHIPDV QFFNCDDEQR
     E