RP8L4_ARATH
ID RP8L4_ARATH Reviewed; 908 AA.
AC Q9FJK8;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Probable disease resistance RPP8-like protein 4;
GN Name=RPP8L4; OrderedLocusNames=At5g48620; ORFNames=K15N18.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Potential disease resistance protein.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family. RPP8/HRT
CC subfamily. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB015468; BAB10695.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95698.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69386.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69387.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69388.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69389.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69390.1; -; Genomic_DNA.
DR EMBL; AK117163; BAC41841.1; -; mRNA.
DR EMBL; BT005968; AAO64903.1; -; mRNA.
DR RefSeq; NP_001331068.1; NM_001344784.1.
DR RefSeq; NP_001331069.1; NM_001344783.1.
DR RefSeq; NP_001331070.1; NM_001344785.1.
DR RefSeq; NP_001331071.1; NM_001344786.1.
DR RefSeq; NP_001331072.1; NM_001344782.1.
DR RefSeq; NP_199673.1; NM_124238.4.
DR AlphaFoldDB; Q9FJK8; -.
DR SMR; Q9FJK8; -.
DR STRING; 3702.AT5G48620.1; -.
DR iPTMnet; Q9FJK8; -.
DR PaxDb; Q9FJK8; -.
DR PRIDE; Q9FJK8; -.
DR ProteomicsDB; 226921; -.
DR EnsemblPlants; AT5G48620.1; AT5G48620.1; AT5G48620.
DR EnsemblPlants; AT5G48620.2; AT5G48620.2; AT5G48620.
DR EnsemblPlants; AT5G48620.3; AT5G48620.3; AT5G48620.
DR EnsemblPlants; AT5G48620.4; AT5G48620.4; AT5G48620.
DR EnsemblPlants; AT5G48620.5; AT5G48620.5; AT5G48620.
DR EnsemblPlants; AT5G48620.6; AT5G48620.6; AT5G48620.
DR GeneID; 834919; -.
DR Gramene; AT5G48620.1; AT5G48620.1; AT5G48620.
DR Gramene; AT5G48620.2; AT5G48620.2; AT5G48620.
DR Gramene; AT5G48620.3; AT5G48620.3; AT5G48620.
DR Gramene; AT5G48620.4; AT5G48620.4; AT5G48620.
DR Gramene; AT5G48620.5; AT5G48620.5; AT5G48620.
DR Gramene; AT5G48620.6; AT5G48620.6; AT5G48620.
DR KEGG; ath:AT5G48620; -.
DR Araport; AT5G48620; -.
DR TAIR; locus:2152536; AT5G48620.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_25_4_1; -.
DR InParanoid; Q9FJK8; -.
DR OMA; DAGCKLP; -.
DR OrthoDB; 169620at2759; -.
DR PhylomeDB; Q9FJK8; -.
DR PRO; PR:Q9FJK8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJK8; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..908
FT /note="Probable disease resistance RPP8-like protein 4"
FT /id="PRO_0000212724"
FT DOMAIN 146..459
FT /note="NB-ARC"
FT REPEAT 575..599
FT /note="LRR 1"
FT REPEAT 600..623
FT /note="LRR 2"
FT REPEAT 842..867
FT /note="LRR 3"
FT COILED 15..57
FT /evidence="ECO:0000255"
FT BINDING 192..199
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 908 AA; 104448 MW; 3111991B17239693 CRC64;
MAEGFVSFGL EKLWDLLSRE SERLQGIDEQ LDGLKRQLRS LQSLLKDADA KKHGSDRVRN
FLEDVKDLVF DAEDIIESYV LNKLRGEGKG VKKHVRRLAR FLTDRHKVAS DIEGITKRIS
DVIGEMQSFG IQQIIDGVRS LSLQERQRVQ REIRQTYPDS SESDLVGVEQ SVEELVGHLV
ENDIYQVVSI AGMGGIGKTT LARQVFHHDL VRRHFDGFAW VCVSQQFTLK HVWQRILQEL
QPHDGNILQM DESALQPKLF QLLETGRYLL VLDDVWKKED WDRIKAVFPR KRGWKMLLTS
RNEGVGIHAD PTCLTFRASI LNPEESWKLC ERIVFPRRDE TEVRLDEEME AMGKEMVTHC
GGLPLAVKAL GGLLANKHTV PEWKRVSDNI GSQIVGGSCL DDNSLNSVNR ILSLSYEDLP
THLKHRFLYL AHFPEDSKIY TQDLFNYWAA EGIYDGSTIQ DSGEYYLEEL VRRNLVIADN
RYLSLEFNFC QMHDMMREVC LSKAKEENFL QIIKDPTSTS TINAQSPSRS RRFSIHSGKA
FHILGHRNNP KVRSLIVSRF EEDFWIRSAS VFHNLTLLRV LDLSRVKFEG GKLPSSIGGL
IHLRYLSLYG AVVSHLPSTM RNLKLLLFLN LRVDNKEPIH VPNVLKEMLE LRYLSLPQEM
DDKTKLELGD LVNLEYLWYF STQHSSVTDL LRMTKLRNLG VSLSERCNFE TLSSSLRELR
NLEMLNVLFS PEIVMVDHMG EFVLDHFIHL KQLGLAVRMS KIPDQHQFPP HLAHIHLVHC
VMKEDPMPIL EKLLHLKSVA LSYGAFIGRR VVCSKGGFPQ LCALGISGES ELEEWIVEEG
SMPCLRTLTI HDCEKLKELP DGLKYITSLK ELKIREMKRE WKEKLVPGGE DYYKVQHIPD
VQFINCDL
